Oxidative Stress in Obesity and Metabolic Syndrome in Children and Adolescents
Oxidative Stress in Obesity and Metabolic Syndrome in Children and Adolescents
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DOI：
10.1159/000342642
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发表时间：
2012-01-01
影响因子：
3.2
通讯作者：
Di Bitonto, Giovanna
中科院分区：
文献类型：
--
作者：
Faienza, Maria Felicia;Francavilla, Ruggiero;Di Bitonto, Giovanna
背景/目标：本研究的目的是探讨在氧化/抗氧化状态的改变，肥胖儿童和不代谢综合征（MetS）。方法：我们招募了25名患有MetS的白人肥胖儿童，30名白人单纯性肥胖儿童和30名白人儿童对照组。我们进行了二羟甲基氨基甲烷-活性氧代谢产物（d-ROM）试验和生物抗氧化潜力（BAP）试验，以评估招募的患者的氧化-抗氧化状态。结果：有和无MetS的肥胖儿童的dROM水平显著较高（p = 0.005）。与对照组相比，MetS和noMetS儿童的总抗氧化能力（BAP水平）降低（p = 0.009）。与MetS受试者相比，无MetS受试者具有较高的d-ROM测试和较低的BAP/d-ROM比值（尽管不显著）。对照组的BAP/d-ROM比值高于非代谢综合征和代谢综合征儿童（p < 0.0001）。青春期前代谢综合征患者的d-ROM水平高于青春期患者（p = 0.03）。d-ROM水平与BMI SDS之间存在直接相关性（p = 0.0005），而BAP与BMI SDS之间存在负相关性（p = 0.004），BAP/d-ROM与BMI SDS之间存在负相关性（p = 0.0001）。结论：这一结果证实，脂肪蓄积在儿童期全身氧化应激的发病机制中起着关键作用。版权所有（C）2012 S. Karger AG，巴塞尔
Background/Aims: The aim of this study was to investigate the alterations in the oxidant/antioxidant status in obese children with and without metabolic syndrome (MetS). Methods: We recruited 25 Caucasian obese children with MetS, 30 Caucasian children with simple obesity and a control group of 30 Caucasian children. We performed diacron-reactive oxygen metabolites (d-ROMs) test and biological antioxidant potential (BAP) test in order to evaluate the oxidant-antioxidant status in recruited patients. Results: dROM level was significantly higher in obese children with and without MetS (p = 0.005). The total antioxidant capacity (BAP level) was reduced in MetS and noMetS children compared to controls (p = 0.009). The subjects without MetS had higher d-ROMs test and lower BAP/d-ROMs ratio than subjects with MetS (although not significant). The ratio BAP/d-ROMs was higher in controls than noMetS and MetS children (p < 0.0001). d-ROM level was higher in prepubertal subjects with MetS than pubertal ones (p = 0.03). A direct correlation was found between d-ROM levels and BMI SDS (p = 0.0005), while an inverse correlation was found between BAP and BMI SDS (p = 0.004) and BAP/d-ROMs and BMI SDS (p = 0.0001). Conclusions: This result confirms that fat accumulation plays a key role in the pathogenesis of systemic oxidative stress already during pediatric age. Copyright (C) 2012 S. Karger AG, Basel