Engineering the synchronization of neuron action potentials using global time-delayed feedback stimulation.
Engineering the synchronization of neuron action potentials using global time-delayed feedback stimulation.
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DOI：
10.1103/physreve.84.066202
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Hudson JL
中科院分区：
文献类型：
--
作者：
Rusin CG;Johnson SE;Kapur J;Hudson JL
我们在实验中演示了使用连续的、时间延迟的反馈刺激来控制神经元动作电位的同步。以单个突触分离培养的海马神经元为实验材料，建立了基于时相的模型。这些模型被用来确定在通过全局时滞相互作用耦合的一对神经元的动作电位中产生所需同步行为所需的刺激参数。使用动态钳位系统进行的测量证实了由实验构建的相位模型预测的同步状态的产生。然后，该模型被用来外推必要的反馈刺激参数，以扰乱大量全球相互作用神经元的动作电位同步。
We experimentally demonstrate the use of continuous, time-delayed, feedback stimulation for controlling the synchronization of neuron action potentials. Phase-based models were experimentally constructed from a single synaptically isolated cultured hippocampal neuron. These models were used to determine the stimulation parameters necessary to produce the desired synchronization behavior in the action potentials of a pair of neurons coupled through a global time-delayed interaction. Measurements made using a dynamic clamp system confirm the generation of the synchronized states predicted by the experimentally constructed phase model. This model was then utilized to extrapolate the feedback stimulation parameters necessary to disrupt the action potential synchronization of a large population of globally interacting neurons.