Primordial Germ Cells in Mice
Primordial Germ Cells in Mice
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DOI：
10.1101/cshperspect.a008375
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发表时间：
2012-11-01
影响因子：
7.2
通讯作者：
Yamaji, Masashi
中科院分区：
文献类型：
--
作者：
Saitou, Mitinori;Yamaji, Masashi
生殖细胞发育通过基因组功能的遗传和表观遗传调节产生全能性。原始生殖细胞（Primitive germ cells，PGCs）是发育过程中最早形成的生殖细胞群，是卵母细胞和精原细胞的直接前体细胞。我们在这里总结了最近的研究结果有关的机制PGC的发展在小鼠。我们专注于PGC规范，潜在的多能性，和表观遗传重编程PGC和战略的生殖细胞发育重建培养中使用多能干细胞的转录和信号传导机制。对生殖细胞发育的持续研究可能导致体外全能性的产生，这将对生物科学和医学产生深远的影响。
Germ cell development creates totipotency through genetic as well as epigenetic regulation of the genome function. Primordial germ cells (PGCs) are the first germ cell population established during development and are immediate precursors for both the oocytes and spermatogonia. We here summarize recent findings regarding the mechanism of PGC development in mice. We focus on the transcriptional and signaling mechanism for PGC specification, potential pluripotency, and epigenetic reprogramming in PGCs and strategies for the reconstitution of germ cell development using pluripotent stem cells in culture. Continued studies on germ cell development may lead to the generation of totipotency in vitro, which should have a profound influence on biological science as well as on medicine.