ABSORPTION AND CIRCULAR-DICHROISM STUDIES OF A GOLD (I)-DNA COMPLEX
ABSORPTION AND CIRCULAR-DICHROISM STUDIES OF A GOLD (I)-DNA COMPLEX
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DOI：
10.1016/0162-0134(84)85036-9
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发表时间：
1984-01-01
影响因子：
3.9
通讯作者：
DABROWIAK, JC
中科院分区：
文献类型：
--
作者：
BLANK, CE;DABROWIAK, JC
研究了含Au（I）的抗关节炎药物Ridaura及其Au（I）配合物与DNA的结合性质。吸收和圆二色性光谱表明，如果金离子具有容易置换的配体，例如，Cl-或Br-，Au（I）能以非变性方式与小牛胸腺DNA相互作用。用4种DNA核苷的吸收研究表明，鸟嘌呤和胞嘧啶碱基在Au（I）DNA相互作用中是重要的。
The DNA binding properties of the Au(I)-containing antiarthritic drug Ridaura and related Au(I) complexes were investigated. Absorption and circular dichroism spectroscopy show that if the gold ion possesses an easily displaced ligand, e.g., Cl- or Br-, Au(I) is capable of interacting, in a nondenaturing fashion, with calf thymus DNA. Absorption studies with the 4 DNA nucleosides suggest that guanine and cytosine bases are important in the Au(I)DNA interaction.