Small fibre neuropathy in sarcoidosis
Small fibre neuropathy in sarcoidosis
复制标题
DOI：
10.1016/s0140-6736(02)08912-2
复制
发表时间：
2002-06-15
期刊：
影响因子：
168.9
通讯作者：
Drent, M
中科院分区：
文献类型：
--
作者：
Hoitsma, E;Marziniak, M;Drent, M
一些结节病患者有不明原因的疼痛和感觉不良。我们对31例伴有疼痛或自主神经功能障碍的结节病患者进行了定量感觉测试。25名患者的热敏感性、冷敏感性或两者都有所降低。在连续7例患者的穿刺活检皮肤样本中测量表皮内神经纤维密度（IENFD）。与对照组相比，所有7例患者的IENFD均降低，这证实了这些患者存在小纤维神经病变。一些结节病患者可能有小纤维神经病变，并累及自主神经。
Some patients with sarcoidosis have unexplained pain and dysaesthesia. We did quantitative sensory testing in 31 sarcoidosis patients with pain or autonomic dysfunction. 25 patients had reduced warmth sensitivity, cold sensitivity, or both. Intraepidermal nerve fibre density (IENFD) was measured in punch biopsy skin samples in seven consecutive patients. All seven patients had reduced IENFD compared with controls, which confirmed the presence of small fibre neuropathy in these patients. Some patients with sarcoidosis may have small fibre neuropathy with autonomic involvement.