Inhibition of biofilm development of uropathogens by curcumin - An anti-quorum sensing agent from Curcuma longa
Inhibition of biofilm development of uropathogens by curcumin - An anti-quorum sensing agent from Curcuma longa
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DOI：
10.1016/j.foodchem.2012.08.002
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发表时间：
2014-04-01
期刊：
影响因子：
8.8
通讯作者：
Ravi, Arumugam Veera
中科院分区：
文献类型：
--
作者：
Packiavathy, Issac Abraham Sybiya Vasantha;Priya, Selvam;Ravi, Arumugam Veera
尿路感染主要是由尿路病原体依赖群体感应（QS）的生物膜形成能力所引起。在本研究中，来自姜黄的一种抗群体感应（抗 - QS）剂姜黄素被证明可抑制尿路病原体（如大肠杆菌、铜绿假单胞菌PAO1、奇异变形杆菌和粘质沙雷氏菌）的生物膜形成，可能是通过干扰它们的QS系统。在光学显微镜和共聚焦激光扫描显微镜下检测了姜黄素对尿路病原体的抗生物膜潜力以及其对成熟生物膜的破坏效果。还发现姜黄素处理可减弱尿路病原体的QS依赖因子，如胞外多糖产生、藻酸盐产生、游动和群集运动能力。此外，有记录表明姜黄素提高了一种标记菌株和尿路病原体对常规抗生素的敏感性。（C）2012爱思唯尔有限公司。保留所有权利。
Urinary tract infection is caused primarily by the quorum sensing (QS)-dependent biofilm forming ability of uropathogens. In the present investigation, an anti-quorum sensing (anti-QS) agent curcumin from Curcuma longa (turmeric) was shown to inhibit the biofilm formation of uropathogens, such as Escherichia coli, Pseudomonas aeruginosa PAO1, Proteus mirabilis and Serratia marcescens, possibly by interfering with their QS systems. The antibiofilm potential of curcumin on uropathogens as well as its efficacy in disturbing the mature biofilms was examined under light microscope and confocal laser scanning microscope. The treatment with curcumin was also found to attenuate the QS-dependent factors, such as exopolysaccharide production, alginate production, swimming and swarming motility of uropathogens. Furthermore, it was documented that curcumin enhanced the susceptibility of a marker strain and uropathogens to conventional antibiotics. (C) 2012 Elsevier Ltd. All rights reserved.