Rapid Detection of the Antibiotic Sulfamethazine in Pig Body Fluids by Paper Spray Mass Spectrometry
Rapid Detection of the Antibiotic Sulfamethazine in Pig Body Fluids by Paper Spray Mass Spectrometry
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DOI：
10.1021/acs.jafc.9b00500
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发表时间：
2019-03-13
影响因子：
6.1
通讯作者：
Praneenararat, Thanit
中科院分区：
文献类型：
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作者：
Suraritdechachai, Surased;Charoenpakdee, Chayan;Praneenararat, Thanit
本文报道了一种结合简单萃取和纸喷雾质谱（PS-MS）非致死性检测猪体液中磺胺二甲嘧啶的实用方法。该方法需要最少的样品制备，同时在包括猪全血在内的复杂基质中仍具有高灵敏度和准确度（LOD = 7.9 μ g/L;回收率= 95.4-103.7%），猪血清（LOD = 11.5 μ g/L;回收率= 103.2-106.2%）和合成尿（LOD = 11.2 μ g/L;回收率= 99.1-103.2%）。鉴于体液和可食用组织中磺胺二甲嘧啶水平之间的已知相关性，该方法显示出作为药物快速检测的实用和非致死性解决方案的巨大前景，这可以大大有助于畜牧业的管理决策。
We report herein a practical method for nonlethal detection of the antibiotic sulfamethazine in pig body fluids via the combination of simple extraction and paper spray mass spectrometry (PS-MS). This method requires minimal sample preparation while still providing high sensitivities and accuracies in complex matrices including pig whole blood (LOD = 7.9 mu g/L; recovery = 95.4-103.7%), pig serum (LOD = 11.5 mu g/L; recovery = 103.2-106.2%), and synthetic urine (LOD = 11.2 mu g/L; recovery = 99.1-103.2%). Given a known correlation between the level of sulfamethazine in body fluids and edible tissues, this method shows great promise as a practical and nonlethal solution for rapid testing of the drug, which can substantially aid managerial decision in the livestock industry.