Identification and characterization of functional long noncoding RNAs in cancer.
Identification and characterization of functional long noncoding RNAs in cancer.
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DOI：
10.1096/fj.202001951r
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发表时间：
2020-12
期刊：
影响因子：
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通讯作者：
Dimitrova N
中科院分区：
文献类型：
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作者：
Olivero CE;Dimitrova N
长链非编码RNA（lncRNA）已成为影响疾病状态的各种细胞过程的关键调节因子。特别是，许多lncRNA在癌症中是遗传或表观遗传失调的。然而，lncRNA的改变是否是癌症进展过程中获得的乘客或可以作为致瘤驱动因素是一个正在进行的研究主题。在这篇综述中，我们研究了目前识别癌症相关lncRNA的方法，并强调了评估其作为癌症驱动因素的生物学意义的重要考虑因素。
Long noncoding RNAs (lncRNAs) have emerged as key regulators in a variety of cellular processes that influence disease states. In particular, many lncRNAs are genetically or epigenetically deregulated in cancer. However, whether lncRNA alterations are passengers acquired during cancer progression or can act as tumorigenic drivers is a topic of ongoing investigation. In this review, we examine the current methodologies underlying the identification of cancer‐associated lncRNAs and highlight important considerations for evaluating their biological significance as cancer drivers.