Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke.
Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke.
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DOI：
10.1093/texcom/tgab005
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发表时间：
2021
影响因子：
--
通讯作者：
Schnur TT
中科院分区：
文献类型：
--
作者：
Martin RC;Ding J;Hamilton AC;Schnur TT
大量的行为证据表明存在可分离的工作记忆（WM）成分来维持语音和语义信息。相比之下，只有少数研究使用功能性神经成像解决了语音与语义WM的神经基础，没有人使用病变-症状映射（LSM）方法。在这里，我们解决了这一差距，报告了一项针对94名左半球中风急性期患者的语音和语义WM的多元LSM研究。在急性阶段的测试避免了大脑重组和采用病人的任务执行策略的问题。LSM分析每个WM成分控制的其他WM成分和单个单词水平的语义和语音知识。对于语音WM，发现的区域包括被认为是语音存储的边缘上回，以及一些可能与内部排练相关的皮层和皮层下区域。对于语义脑损伤，下额区和角回被发现。因此，这些发现为语音和语义WM的可分离系统提供了聚合证据，这些系统与支持这些领域的长期知识表示的系统有所区别。
Substantial behavioral evidence implies the existence of separable working memory (WM) components for maintaining phonological and semantic information. In contrast, only a few studies have addressed the neural basis of phonological versus semantic WM using functional neuroimaging and none has used a lesion-symptom mapping (LSM) approach. Here, we address this gap, reporting a multivariate LSM study of phonological and semantic WM for 94 individuals at the acute stage of left hemisphere stroke. Testing at the acute stage avoids issues of brain reorganization and the adoption of patient strategies for task performance. The LSM analyses for each WM component controlled for the other WM component and semantic and phonological knowledge at the single word level. For phonological WM, the regions uncovered included the supramarginal gyrus, argued to be the site of phonological storage, and several cortical and subcortical regions plausibly related to inner rehearsal. For semantic WM, inferior frontal regions and the angular gyrus were uncovered. The findings thus provide converging evidence for separable systems for phonological and semantic WM that are distinguished from the systems supporting long-term knowledge representations in those domains.