Different host defences are required to protect mice from primary systemic vs pulmonary infection with the facultative intracellular bacterial pathogen, Francisella tularensis LVS
Different host defences are required to protect mice from primary systemic vs pulmonary infection with the facultative intracellular bacterial pathogen, Francisella tularensis LVS
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DOI：
10.1006/mpat.2001.0489
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发表时间：
2002-03-01
影响因子：
3.8
通讯作者：
Webb, A
中科院分区：
文献类型：
--
作者：
Conlan, JW;KuoLee, R;Webb, A
土拉热弗朗西丝菌是一种人畜共患的兼性细胞内细菌病原体，能够通过多种途径（包括皮肤微擦伤和吸入）引发感染（土拉菌病）。土拉菌LVS全身感染的小鼠模型已被广泛用于揭示潜在的宿主防御机制。这些研究表明，迫切需要中性粒细胞和干扰素-γ（IFN-γ）来对抗由全身途径引发的原发性实验性土拉菌病的早期阶段。然而，令人惊讶的是，本研究表明，这些防御似乎不能对抗由病原体吸入下呼吸道引起的早期肺土拉菌病。结果表明，特定的抗菌宿主防御的有效性不同的入侵部位。因此，根据目前已知的抗弗朗西斯菌防御机制，无法预测针对吸入引发的土拉菌的有效宿主防御机制，这些防御机制已被证明可对抗系统性引发的感染。
Francisella tularensis is a zoonotic, facultative intracellular bacterial pathogen capable of initiating infection, tularemia, via multiple routes including dermal micro-abrasions and inhalation. Mouse models of systemically-initiated infection with F tularensis LVS have been used extensively to reveal potential host defence mechanisms against the pathogen. Such studies have demonstrated the critical need for neutrophils and interferon-gamma (IFN-gamma) to combat the early stages of primary experimental tularaernia initiated by systemic routes. Surprisingly, however, the present study shows that these defences appear not to combat early pulmonary tularaernia initiated by inhalation of the pathogen into the lower airways. The results imply that the effectiveness of particular antibacterial host defences vary with invasion site. Thus, it is impossible to predict effective host defence mechanisms against inhalation-initiated tularaernia from current knowledge of anti-Francisella defences that have been shown to combat systemically-initiated infection.