SPLUNC1 (PLUNC) is expressed in glandular tissues of the respiratory tract and in lung tumours with a glandular phenotype
SPLUNC1 (PLUNC) is expressed in glandular tissues of the respiratory tract and in lung tumours with a glandular phenotype
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DOI：
10.1002/path.1726
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发表时间：
2005-03-01
影响因子：
7.3
通讯作者：
Bingle, CD
中科院分区：
文献类型：
--
作者：
Bingle, L;Cross, SS;Bingle, CD
短PLUNC1（SPLUNC1）是上呼吸道表达的新蛋白家族（PLUNC1）的创始成员，其可能在宿主防御中起作用。它是上呼吸道中最高表达的基因之一，并且该蛋白质已在痰和鼻分泌物中检测到。这项研究首次描述了SPLUNC1在呼吸道人体组织中的精确细胞定位。尽管SPLUNC1存在于上气道的一些上皮细胞中，并覆盖主要气道的表面上皮细胞衬里，但蛋白定位的最重要位点是粘膜下腺体的粘液细胞和导管。在鼻、鼻窦、后舌和扁桃体的小腺体中也观察到强烈染色，表明该蛋白质分泌到这些组织的粘液分泌物中，在那里它可能在宿主防御中起作用。在外周肺组织中未观察到染色。由于SPLUNC1被认为是一种新的肺癌标志物，因此还研究了有限的肺癌组。研究结果表明SPLUNC1通常在腺癌、粘液表皮样癌和细支气管肺泡癌中表达，而在小细胞癌和鳞状细胞癌中不表达。这种表达模式与这些肿瘤的假定表型起源一致，并表明SPLUNC1可能是肺癌的有用标志物。版权所有（C）2005大不列颠和爱尔兰病理学会。出版社：John Wiley S Sons，Ltd
Short PLUNC1 (SPLUNC1) is the founding member of a novel family of proteins (PLUNC) of expressed in the upper respiratory tract that may function in host defence. It is one of the most highly expressed genes in the upper airways and the protein has been detected in sputum and nasal secretions. This study describes, for the first time, the precise cellular localization of SPLUNC1 in human tissues from the respiratory tract. Although SPLUNC1 is found in some epithelial cells of the upper airways and coats the surface epithelial cell lining of the major airways, the most significant site of protein localization is in mucous cells and ducts of submucosal glands. Intense staining is also seen in minor glands of the nose, sinuses, posterior tongue and tonsil, suggesting that the protein is secreted into mucoid secretions of these tissues, where it probably functions in host defence. No staining was seen in peripheral lung tissue. As SPLUNC1 has been suggested to be a novel lung cancer marker, a limited panel of lung cancers was also studied. The findings suggest that SPLUNC1 is commonly expressed in adenocarcinomas, muco-epidermoid carcinoma, and bronchio-alveloar carcinoma, and is absent from small-cell carcinoma and squamous cell carcinoma. This expression pattern is consistent with the presumed phenotypic origin of these tumours and suggests that SPLUNC1 may be a useful marker for lung cancer. Copyright (C) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley S Sons, Ltd.