Maternal Serum Granulocyte Colony-Stimulating Factor Levels and Spontaneous Preterm Birth
Maternal Serum Granulocyte Colony-Stimulating Factor Levels and Spontaneous Preterm Birth
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DOI：
10.1089/jwh.2008.0883
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发表时间：
2009-01-01
影响因子：
3.5
通讯作者：
Chegini, Nasser
中科院分区：
文献类型：
--
作者：
Whitcomb, Brian W.;Schisterman, Enrique F.;Chegini, Nasser
目的：早产（PTB）仍然是高发病率的一个原因，其病因难以捉摸。先前的研究表明，PTB 与妊娠 28 周时血清中粒细胞集落刺激因子 (GCSF) 水平升高有关。 G-CSF 是一种造血细胞因子，介导妊娠期间白细胞的增加，并可能在胎盘形成中发挥作用。我们评估了妊娠早期和中期的母体血清 G-CSF 与 PTB 之间的关联。方法：使用围产期合作项目 (CPP) 从正常妊娠 (n = 394) 和 PTB (n = 31)（定义为妊娠 37 周前分娩）的妇女收集的血清样本来评估 G-CSF 水平。使用线性回归评估G-CSF与出生时胎龄（GA）的关系。 Logistic 回归（以样本提供时的 GA 为条件）用于模拟 G-CSF 和 PTB 之间的关联。结果：G-CSF 与出生胎龄显着相关（p = 0.02）。在条件逻辑回归模型中，G-CSF 与 PTB 显着相关，每增加一个标准差 (SD)，调整后的比值比 (AOR) 为 1.52（95% 置信区间 [CI] 1.07, 2.16）。 结论：已表明 G-CSF 对 PTB 的急性影响。在我们的研究中，我们观察到妊娠中期早期较高的血清 G-CSF 水平与 PTB 之间存在关联，这表明 PTB 是在妊娠早期（如果不是之前）开始的最终过程。
Objective: Preterm birth (PTB) remains a cause of substantial morbidity with an elusive etiology. Previous studies suggested an association of PTB with elevated serum levels of granulocyte colony-stimulating factor (GCSF) at 28 weeks gestation. G-CSF, a hematopoietic cytokine, mediates the increase in leukocytes in pregnancy and may play a role in placentation. We evaluated the association between maternal serum G-CSF in the first and second trimesters and PTB.Methods: Serum samples collected for the Collaborative Perinatal Project (CPP) from women with normal pregnancy (n = 394) and PTB (n = 31), defined as delivery before 37 weeks gestation, were used to assess G-CSF levels. Linear regression was used to evaluate the relation of G-CSF with gestational age (GA) at birth. Logistic regression, conditional on GA at sample provision, was used to model the association between G-CSF and PTB.Results: G-CSF was significantly associated with gestational age at birth (p = 0.02). In conditional logistic regression models, G-CSF was significantly associated with PTB, with an adjusted odds ratio (AOR) of 1.52 (95% confidence interval [CI] 1.07, 2.16) per standard deviation (SD) increase.Conclusions: Acute effects of G-CSF on PTB have been suggested. In our study we observed an association of higher serum G-CSF levels early in the second trimester with PTB, suggesting PTB as the culmination process beginning early in, if not before, pregnancy.