Safety, tolerance, and pharmacokinetics of iodixanol injection, a nonionic, isosmolar, hexa-iodinated contrast agent
Safety, tolerance, and pharmacokinetics of iodixanol injection, a nonionic, isosmolar, hexa-iodinated contrast agent
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DOI：
10.1016/s1076-6332(05)80362-9
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发表时间：
1996-09-01
影响因子：
4.8
通讯作者：
Grynne, B
中科院分区：
文献类型：
--
作者：
Fountaine, H;Harnish, P;Grynne, B
理由和目标。本文综述了碘克沙醇的临床化学参数和耐受性，碘克沙醇是一种新开发的二聚体，比例为6的放射造影剂，通过平衡添加电解质，在所有浓度下均与血浆等渗。我们总结了已完成的试验碘克沙醇。碘克沙醇给药后股动脉血流量的增加明显小于大多数其他非离子型造影剂。碘克沙醇对肾小管功能的影响似乎小于其他非离子介质，与碘海醇和碘克沙酸不同，正常患者给予碘克沙醇后的不良事件发生率与阴性反应风险增加的患者（既往对造影剂给药有不良反应的患者）基本相同。碘克沙醇给药后的风险在正常患者和有其他风险因素的患者中也相似，包括有充血性心力衰竭、肾功能不全或疾病、哮喘、糖尿病、高血压或血管疾病病史的患者。碘克沙醇与碘克沙酸相比，注射相关的发热和疼痛感显著降低。心脏电生理测量和收缩力显示碘克沙醇的干扰最小。碘克沙醇是一种安全有效的非离子等渗造影剂，可提供临床优势。
Rationale and Objectives. A review of clinical-chemical parameters and tolerability of iodixanol is presented, Iodixanol is a newly developed dimeric, ratio 6 radiographic contrast medium formulated to be isotonic to plasma in all concentrations by the balanced addition of electrolytes. We summarize completed trials of iodixanol.Results. The increase in femoral blood flow following administration of iodixanol was significantly smaller than that seen with most other nonionic contrast media. Iodixanol appears to have less impact than other nonionic media on renal tubular function, Unlike iohexol and ioxaglate, the rate of adverse events after iodixanol administration was essentially the same for normal patients as for patients at increased risk for negative reactions (patients with previous adverse reactions to contrast administration). The risk following administration of iodixanol also appears to be similar in normal patients and in patients with Other risk factors, including those with a history of congestive heart failure, renal insufficiency or disease, asthma, diabetes, hypertension, or vascular disease. A significant reduction in the sensation of injection-associated heat and pain was noted for iodixanol versus ioxaglate. Cardiac electrophysiologic measurements and contractility revealed minimal interference from iodixanol.Conclusion. Iodixanol is a safe and effective nonionic, isotonic contrast medium that may offer clinical advantages.