The Potential of microRNAs for Stem Cell-based Therapy for Degenerative Skeletal Diseases.
The Potential of microRNAs for Stem Cell-based Therapy for Degenerative Skeletal Diseases.
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DOI：
10.1007/s40610-017-0076-4
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Oreffo ROC
中科院分区：
文献类型：
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作者：
Budd E;Waddell S;de Andrés MC;Oreffo ROC
退行性骨骼疾病包括骨关节炎(OA)和骨质疏松症(OP)，是组织再生减弱的结果，并导致疼痛状况，治疗选择有限。预防措施限制骨性关节炎和骨质疏松症的发病仍然是一个重要的临床需求。已知microRNAs(MiRNAs)参与干细胞的分化，与干细胞治疗相结合可以诱导骨骼再生，并有可能预防骨性关节炎和骨质疏松症的发生。干细胞和miRNA的结合已经成功地在体内再生了骨和软骨。MiRNAs，包括已知参与软骨分化的miR-146b，可以为干细胞治疗、修复关节软骨缺陷、预防OA的发生或为OP的干细胞治疗提供创新靶点。该综述讨论了骨骼干细胞(SSCs)与候选miRNAs的结合在骨骼再生医学的细胞治疗中的应用。
Degenerative skeletal disorders including osteoarthritis (OA) and osteoporosis (OP) are the result of attenuation of tissue regeneration and lead to painful conditions with limited treatment options. Preventative measures to limit the onset of OA and OP remain a significant unmet clinical need. MicroRNAs (miRNAs) are known to be involved in the differentiation of stem cells, and in combination with stem cell therapy could induce skeletal regeneration and potentially prevent OA and OP onset. The combination of stem cells and miRNA has been successful at regenerating the bone and cartilage in vivo. MiRNAs, including miR-146b known to be involved in chondrogenic differentiation, could provide innovative targets for stem cell-based therapy, for the repair of articular cartilage defects forestalling the onset of OA or in the generation of a stem cell-based therapy for OP. This review discusses the combination of skeletal stem cells (SSCs) and candidate miRNAs for application in a cell-based therapy approach for skeletal regenerative medicine.