Molarless-induced changes of spines in hippocampal region of SAMP8 mice
Molarless-induced changes of spines in hippocampal region of SAMP8 mice
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DOI：
10.1016/j.brainres.2005.07.038
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发表时间：
2005-09-28
期刊：
影响因子：
2.9
通讯作者：
Onozuka, M
中科院分区：
文献类型：
--
作者：
Kubo, K;Iwaku, F;Onozuka, M
在迷宫实验中，我们观察了无磨牙状态对SAMP8小鼠海马区锥体细胞树突棘的影响，以比较其对学习能力的影响。无臼齿状态仅在表现出学习能力降低的老年小鼠中导致CA1锥体细胞脊椎数量的减少。结果表明，无磨牙状态参与了海马区突触输入活动的减弱。(C)2005 Elsevier B.V.保留所有权利。
We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in companson to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced learning ability. The results suggest the involvement of the molarless condition in an attenuation of input activities in the hippocampal synapses. (c) 2005 Elsevier B.V. All rights reserved.