Hantavirus pulmonary syndrome in Panama: Identification of novel Hantaviruses and their likely reservoirs
Hantavirus pulmonary syndrome in Panama: Identification of novel Hantaviruses and their likely reservoirs
复制标题
DOI：
10.1006/viro.2000.0563
复制
发表时间：
2000-11-10
期刊：
影响因子：
3.7
通讯作者：
Nichol, ST
中科院分区：
文献类型：
--
作者：
Vincent, MJ;Quiroz, E;Nichol, ST
汉坦病毒肺综合征（HPS）是一种由啮齿动物传播的汉坦病毒引起的严重呼吸道疾病，死亡率很高，此前已在美国和加拿大以及南美洲中部和南部发现。1999年底和2000年初，巴拿马的洛斯桑托斯报告了一次与HPS相容的急性疾病爆发，12例疑似病例中有3例死亡（25%）。检测患者血清中汉坦病毒特异性抗体，逆转录-聚合酶链反应检测病毒RNA。病毒基因组N-、G1-和G2-编码片段的序列分析表明，这是一种新的汉坦病毒，即Choclo病毒。对该地区捕获的啮齿动物进行的血清学和病毒遗传学分析表明，Oligoryzomys fulvescens可能是HPS相关Choclo病毒的宿主。此外，Zygodontomys brevicauda啮齿动物被证明携带另一种遗传独特的汉坦病毒。卡拉巴索病毒(C)北京大学出版社.
Hantavirus pulmonary syndrome (HPS), a severe respiratory disease with high mortality caused by rodent-borne hantaviruses, has previously been identified in the United States and Canada as well as central and southern South America. In late 1999 and early 2000, an outbreak of acute illness compatible with HPS was reported in Los Santos, Panama, with the death of 3 of the 12 (25%) suspected cases. Hantavirus-specific antibodies were detected in patient sera, and virus RNA was detected by reverse transcriptase-polymerase chain reaction. Sequence analysis of virus genome N-, G1-, and G2-encoding fragments showed this to be a novel hantavirus, Choclo virus. Serologic and virus genetic analyses of rodents trapped in the area showed Oligoryzomys fulvescens to be the likely reservoir for the HPS-associated Choclo virus. In addition, Zygodontomys brevicauda rodents were shown to harbor another genetically unique hantavirus. Calabazo virus. (C) 2000 Academic Press.