Mitochondrial DNA haplogroup R in the Han population and recovery from septic encephalopathy
Mitochondrial DNA haplogroup R in the Han population and recovery from septic encephalopathy
复制标题
汉族人群线粒体 DNA 单倍群 R 与脓毒性脑病的恢复
DOI：
10.1007/s00134-011-2319-9
复制
发表时间：
2011-10-01
影响因子：
38.9
通讯作者：
Chen, Jianghua
中科院分区：
文献类型：
--
作者：
Yang, Yi;Zhang, Ping;Chen, Jianghua
PurposeTo确定是否主要的线粒体DNA（mtDNA）单倍型组的汉族人与神经功能恢复脓毒性脑病MethodsWe研究了137个人脓毒性脑病谁是顺序进入重症监护室或急诊重症监护室在第一附属医院，医学院，浙江大学和浙江省人民医院。记录28天内的人口统计学和临床数据沿着临床结局。每天计算格拉斯哥昏迷量表（GCS）评分，直至达到15分或直至患者在28天内死亡。对所有研究参与者完成随访。结果MtDNA单倍群R是感染性脑病预后的独立预测因子，是感染性脑病预后的4.053倍。（95%CI 1.803- 9.110，p = 0.001）与非R mtDNA单倍型group.ConclusionIn汉族人群中，mtDNA单倍型R是脓毒性脑病预后的一个强有力的独立预测因子，与非R单倍型个体相比，神经功能恢复的机会增加。我们的研究结果为脓毒性脑病的机制提供了潜在的见解，并揭示了mtDNA单倍型群R是脓毒性脑病结局的独立预测因子。
PurposeTo determine whether the main mitochondrial DNA (mtDNA) haplogroups of the Han people are associated with neurological recovery from septic encephalopathy.MethodsWe studied 137 individuals with septic encephalopathy who were sequentially admitted to the intensive care unit or the emergency intensive care unit at the First Affiliated Hospital, College of Medicine, Zhejiang University, and the People’s Hospital of Zhejiang Province. Demographic and clinical data were recorded along with clinical outcome over 28 days. The Glasgow coma scale (GCS) score was calculated daily until it reached 15 or until the patient died during the 28-day period. Follow-up was completed for all study participants. We then determined the mtDNA haplogroups of the patients by analyzing sequences of hypervariable mtDNA segments and testing diagnostic polymorphisms in the mtDNA coding region with DNA probes.ResultsMtDNA haplogroup R, one of the main mtDNA haplogroups of the Han people, was a strong independent predictor of outcome following septic encephalopathy, conferring a 4.053-fold (95% CI 1.803–9.110,p= 0.001) increased chance of neurological recovery within 28 days compared with those with a non-R mtDNA haplogroup.ConclusionIn the Han population, mtDNA haplogroup R is a strong independent predictor of the outcome of septic encephalopathy, conferring an increased chance of neurological recovery compared with individuals with a non-R haplogroup. Our results provide potential insights into the mechanisms involved in septic encephalopathy, and reveal that the mtDNA haplogroup R is an independent predictor of the outcome of septic encephalopathy.