Synthesis of chiral 1,1'-iminodicarboxylic acid derivatives from alpha-amino acids, aldehydes, isocyanides, and alcohols by the diastereoselective five-center four-component reaction
Synthesis of chiral 1,1'-iminodicarboxylic acid derivatives from alpha-amino acids, aldehydes, isocyanides, and alcohols by the diastereoselective five-center four-component reaction
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DOI：
10.1002/anie.199601731
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发表时间：
1996-02-02
期刊：
影响因子：
--
通讯作者：
Ugi, I
中科院分区：
文献类型：
--
作者：
Demharter, A;Horl, W;Ugi, I
不仅高达98%的产率，而且高达84%的非对映异构体过量是这种用于在一锅反应中合成亚氨基二羧酸衍生物的有效且通用的多组分反应的优点[Eq.（a）]。
Not only yields of up to 98% but also diastereomeric excesses of up to 84% are the advantages of this effective and versatile multicomponent reaction for the synthesis of iminodicarboxylic acid derivatives in a one‐pot reaction [Eq.(a)].