Multicenter Randomized Comparison of LigaSure Versus Conventional Surgery for Gastrointestinal Carcinoma
Multicenter Randomized Comparison of LigaSure Versus Conventional Surgery for Gastrointestinal Carcinoma
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DOI：
10.1007/s00595-009-4234-z
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发表时间：
2010-11-01
期刊：
影响因子：
2.5
通讯作者：
Ryu, Munemasa
中科院分区：
文献类型：
--
作者：
Takiguchi, Nobuhiro;Nagata, Matsuo;Ryu, Munemasa
目的。我们在五家肿瘤专科医院进行了这项随机试验，比较LigaSure血管密封系统与常规方法在胃肠道肿瘤手术中的应用。可切除的胃癌或结直肠癌患者根据密封信封随机分为LigaSure组（n = 100）和常规手术组（n = 74）。比较两组手术资料。两组在手术时间、出血量、术后并发症或住院时间方面无显著差异。然而,在医院发生的程序,LigaSure被关联到一个操作时间短(173 + / - 43分钟的胃癌和结直肠癌157 + / - 43分钟vs 211 + / - 55分钟和202 + / - 55分钟常规手术;P = 0.0046, P = 0.0200),减少失血(300 + / - 196毫升和150 + / - 133 ml,分别vs 453 387毫升和382 + / - 444毫升;P = 0.0482, P = 0.0465) .Conclusions。LigaSure对于胃癌和结直肠癌的大面积淋巴结清扫手术都是安全的。使用有效，该设备似乎减少了操作时间和失血，尽管这需要在更大的系列确认。
Purpose. We conducted this randomized trial to compare the LigaSure Vessel Sealing System with conventional methods in gastrointestinal carcinoma surgery at five specialty cancer hospitals.Methods. Patients with resectable stomach or colorectal cancers were randomized to the LigaSure (n = 100) or conventional surgery (n = 74) groups according to sealed envelopes. The operative data were compared.Results. There were no significant differences in operating times, blood loss, postoperative complications, or hospital stay. However, at the hospital where most of the procedures took place, the LigaSure was associated with a shorter operating time (173 +/- 43 min for gastric carcinoma and 157 +/- 43 min for colorectal carcinoma vs 211 +/- 55 min and 202 +/- 55 min for conventional surgery; P = 0.0046 and P = 0.0200, respectively) and less blood loss (300 +/- 196 ml and 150 +/- 133 ml, respectively, vs 453 387 ml and 382 +/- 444 ml; P = 0.0482 and P = 0.0465, respectively).Conclusions. The LigaSure is safe for both gastric and colorectal cancer surgery with extended lymph node dissection. Used effectively, the device appears to reduce operating times and blood loss, although this requires confirmation in a larger series.