Calcium in the control of renin secretion: Ca2+ influx as an inhibitory signal.
Calcium in the control of renin secretion: Ca2+ influx as an inhibitory signal.
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钙控制肾素分泌：Ca2+流入作为抑制信号。
DOI：
10.1152/ajprenal.1981.240.1.f70
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Fray,JC
中科院分区：
文献类型：
--
作者：
Park,CS;Han,DS;Fray,JC
研究了血管紧张素II、抗利尿激素、哇巴因和高K+浓度体外抑制肾皮质切片分泌肾素的机制。这些药物的抑制作用被 Ca 拮抗剂维拉帕米阻断。此外，肾上腺素刺激肾素分泌，其刺激作用被哇巴因阻断。这些结果支持这样的假设：Ca2+流入肾小球旁细胞起到抑制信号的作用，而Ca2+流出是肾素分泌的刺激信号。降低孵育温度可极大地刺激肾素分泌，表明肾素分泌不依赖于能量。讨论了肾小球旁细胞的 Ca2+ 可能激活一种酶，然后调节肾素分泌过程的一些连续步骤，从而控制肾素分泌速率的可能性。
The mechanism for the inhibition of renin secretion in vitro from renal cortical slices by angiotensin II, antidiuretic hormone, ouabain, and high K+ concentration was studied. The inhibitory effect of these agents was blocked by a Ca antagonist, verapamil. In addition, epinephrine stimulated renin secretion and its stimulatory action was blocked by ouabain. These results support the hypothesis that Ca2+ influx into juxtaglomerular cells plays a role as an inhibitory signal whereas Ca2+ efflux is a stimulatory signal for renin secretion. Renin secretion was greatly stimulated by lowering incubation temperature, indicating that renin secretion is not energy dependent. The possibility is discussed that Ca2+ of juxtaglomerular cells might activate an enzyme(s) that then modulates some sequential steps of renin secretory processes, thereby controlling the rate of renin secretion.