Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers.
Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers.
复制标题
DOI：
10.1039/c7cc00506g
复制
发表时间：
2017-03
影响因子：
4.9
通讯作者：
Gesi Wen;Wenjing Qin;Daoyuan Chen;Youqiao Wang;Xin Yue;Ziyi Liu;Yingnan Cao;Jun Du;Binhua Zhou;Xianzhang Bu
中科院分区：
文献类型：
--
作者：
Gesi Wen;Wenjing Qin;Daoyuan Chen;Youqiao Wang;Xin Yue;Ziyi Liu;Yingnan Cao;Jun Du;Binhua Zhou;Xianzhang Bu
β 淀粉样蛋白 (Aβ) 寡聚物是引发 AD 发病机制的病原体，但消除它们仍然具有挑战性。我们在此报道了一种天然环肽 tyrocidine A 通过稳定 Aβ 肽的单体状态而非寡聚状态来预防和逆转淀粉样蛋白形成，而无需 Aβ 寡聚体积累。
Amyloid-β (Aβ) oligomers are causative agents triggering AD pathogenesis, but their elimination remains challenging. We herein reported a natural cyclopeptide tyrocidine A prevents and reverses amyloidogenesis without Aβ oligomer accumulation by stabilizing the monomeric, but not the oligomeric state of Aβ peptides.