A light-actuated nanovalve derived from a channel protein
A light-actuated nanovalve derived from a channel protein
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DOI：
10.1126/science.1114760
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发表时间：
2005-07-29
期刊：
影响因子：
56.9
通讯作者：
Feringa, BL
中科院分区：
文献类型：
--
作者：
Koçer, A;Walko, M;Feringa, BL
为了实现纳米级器件控制，我们报道了一种嵌入在膜中的分子阀，该分子阀可以通过长波长紫外线（366纳米）照射打开，然后通过可见光照射重新密封。该阀门由一种通道蛋白组成，该通道蛋白是来自大肠杆菌的大电导机械敏感通道（MscL），通过附着合成化合物进行修饰，这些化合物经过紧密诱导的电荷分离，可以可逆地打开和关闭一个3纳米的孔。该系统是兼容的经典封装系统，脂质体和外部光化学控制运输通过通道实现。
Toward the realization of nanoscale device control, we report a molecular valve embedded in a membrane that can be opened by illumination with long-wavelength ultraviolet (366 nanometers) tight and then resealed by visible irradiation. The valve consists of a channel protein, the mechanosensitive channel of large conductance (MscL) from Escherichia coli, modified by attachment of synthetic compounds that undergo tight-induced charge separation to reversibly open and close a 3-nanometer pore. The system is compatible with a classical encapsulation system, the liposome, and external photochemical control over transport through the channel is achieved.