Bright and stable core-shell fluorescent silica nanoparticles
Bright and stable core-shell fluorescent silica nanoparticles
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DOI：
10.1012/nl0482478
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发表时间：
2005-01-01
期刊：
影响因子：
10.8
通讯作者：
Wiesner, U
中科院分区：
文献类型：
--
作者：
Ow, H;Larson, DR;Wiesner, U
描述了一类由改进的 Stober 合成法合成的高度荧光和光稳定的核壳纳米颗粒，尺寸范围为 20-30 nm。这些纳米粒子在溶液中是单分散的，比其组成的荧光团亮 20 倍，并且光稳定性更高，并且适合对生物大分子进行特定标记，用于生物成像实验。封装荧光团的光物理特性与其溶液特性不同。这提高了调整纳米粒子结构以增强辐射性能的可能性，使其成为各种应用的有吸引力的材料平台。
A class of highly fluorescent and photostable core-shell nanoparticles from a modified Stober synthesis in the size range of 20-30 nm is described. These nanoparticles are monodisperse in solution, 20 times brighter, and more photostable than their constituent fluorophore, and are amenable to specific labeling of biological macromolecules for bioimaging experiments. The photophysical characteristics of the encapsulated fluorophores differ from their solution properties. This raises the possibility of tuning nanoparticle structure toward enhanced radiative properties, making them an attractive material platform for a diverse range of applications.