Biomarkers of Allostatic Load as Correlates of Impairment in Youth with Chronic Pain: An Initial Investigation.
Biomarkers of Allostatic Load as Correlates of Impairment in Youth with Chronic Pain: An Initial Investigation.
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DOI：
10.3390/children8080709
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发表时间：
2021-08-18
期刊：
影响因子：
--
通讯作者：
Enlow MB
中科院分区：
文献类型：
--
作者：
Nelson S;Bento S;Enlow MB
儿科慢性疼痛是常见的，并负责重大的医疗保健负担。然而，儿童慢性疼痛的发展和/或维持的机制仍然知之甚少。非稳态负荷（AL），即显着或长期压力后神经系统的磨损，已被认为在慢性疼痛的维持中发挥作用，但很少有研究探讨了这种可能性。研究中的这一差距尤其值得注意，因为儿童期不良经历（ACE;虐待/忽视等）的暴露率很高。和心理压力。因此，目前的研究旨在初步检查AL在寻求治疗的儿科疼痛人群中的测量。在已经安排的新患者疼痛评估期间收集生物标志物，包括唾液皮质醇，脱氢表雄酮（DHEA）和C-反应蛋白，以及腰臀比，体重指数和血压。共有61名患有慢性疼痛的儿童和青少年（法师= 14.47岁; 88.5%为女性和白色/高加索人）完成了研究程序，并被纳入分析。初步结果表明，多因素AL复合材料在三级疼痛治疗环境中进行评估是可行的，并且超过50%的慢性疼痛青年被归类为AL高风险（两个或多个风险因素）。此外，研究发现，个别AL危险因素与功能障碍显着相关，AL可能会缓和心理社会和功能结果之间的关联。鉴于本研究的试点性质，结果应用于通知未来的调查与更大，更多样化的儿科疼痛样本。
Pediatric chronic pain is common and responsible for significant healthcare burden. However, the mechanisms underlying the development and/or maintenance of pediatric chronic pain remain poorly understood. Allostatic load (AL), or wear and tear on the nervous system following significant or prolonged stress, has been proposed to play a role in the maintenance of chronic pain, but minimal research has examined this possibility. This gap in research is particularly notable given the high exposure to adverse childhood experiences (ACEs; abuse/neglect, etc.) and psychological stress in this population. Accordingly, the current study aimed to preliminarily examine the measurement of AL in a treatment-seeking pediatric pain population. Biomarkers were collected during an already scheduled new patient pain evaluation and included salivary cortisol, dehydroepiandrosterone (DHEA), and C-reactive protein, in addition to waist–hip ratio, body-mass index, and blood pressure. A total of 61 children and adolescents with chronic pain (Mage = 14.47 years; 88.5% female and white/Caucasian) completed study procedures and were included in analyses. Preliminary results indicated that a multifactorial AL composite is feasible to assess for in a tertiary pain treatment setting and that over 50% of youth with chronic pain were classified as high risk for AL (two or more risk factors). Further, it was found that individual AL risk factors were significantly associated with functional disability and that AL may moderate the association between psychosocial and functional outcomes. Given the pilot nature of this study, results should be used to inform future investigations with larger and more diverse pediatric pain samples.
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DOI：
10.1016/j.jpeds.2018.06.051
发表时间：
2018-11
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Kaufman J;Montalvo-Ortiz JL;Holbrook H;O'Loughlin K;Orr C;Kearney C;Yang BZ;Wang T;Zhao H;Althoff R;Garavan H;Gelernter J;Hudziak J
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3.3
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10.1097/mpg.0b013e3181de0639
发表时间：
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影响因子：
2.9
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影响因子：
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影响因子：
4
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