Childhood cancer in relation to a modified residential wire code.
Childhood cancer in relation to a modified residential wire code.
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DOI：
10.1289/ehp.9310176
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发表时间：
1993-04-22
影响因子：
10.4
通讯作者：
Kaune WT
中科院分区：
文献类型：
--
作者：
Savitz DA;Kaune WT
几项研究发现，电线配置代码（代表历史住宅磁场暴露）与儿童癌症之间存在关联。Wertheimer-Leeper编码方法被修改，取消了粗原色和细原色之间的区别，只区分开的和旋转的二原色，并将类别数量从五个减少到三个。修改后的代码和测量的磁场之间的关联与原始导线代码的关联相似。修改后的代码被用来重新分析数据，从一个病例对照研究的儿童癌症在丹佛大都市地区。在最初的研究中，1976年至1983年在15岁以下的儿童中诊断出病例，并与通过随机数字拨号选择的对照组进行比较。诊断时住宅的电线代码对于非常高电流配置的住宅产生了2倍及以上的不精确升高，或者对于二分电线代码产生了适度的1.5倍升高。相比之下，改良Wertheimer-Leeper代码生成的风险估计值，与低线代码（LWC）分类相比，高线代码（HWC）的风险估计值精确且显著升高，而中线代码（MWC）显示风险几乎没有增加。高线编码得出的总癌症的比值比为1.9（95% CI：1.1 - 3.2），白血病为2.9（95% CI：1.5 - 5.5），脑癌为2.5（95% CI：1.1 - 5.5），未被儿童癌症的潜在危险因素混淆。这些风险估计值大于二分结果，并且比原始五级导线编码的结果更精确，尽管原始研究的局限性仍然存在，特别是潜在的对照选择偏倚。（250字处删节）
Several studies have found associations between wire configuration codes, a proxy for historical residential magnetic field exposure, and childhood cancer. The Wertheimer-Leeper coding method was modified by eliminating the distinction between thick and thin primaries, distinguishing only between open and spun secondaries, and reducing the number of categories from five to three. The association between the modified code and measured magnetic fields was similar to the association with the original wire code. The modified code was used to reanalyze data from a case-control study of childhood cancer in the Denver metropolitan area. In the original study, cases were diagnosed from 1976 to 1983 among children under age 15 and compared to controls selected through random digit dialing. Wire codes for the residence at diagnosis yielded imprecise elevations of two and above for very high current configuration homes or modest 1.5-fold elevations for a dichotomous wire code. In contrast, the modified Wertheimer-Leeper code generated risk estimates that were both precise and markedly elevated for the high wire code (HWC) compared to low wire code (LWC) classifications, with medium wire code (MWC) showing little or no increase in risk. High wire code yielded odds ratios of 1.9 for total cancers (95% CI: 1.1-3.2), 2.9 for leukemias (95% CI: 1.5-5.5), and 2.5 for brain cancer (95% CI: 1.1-5.5) that were not confounded by measured potential risk factors for childhood cancer. These risk estimates are larger than the dichotomized results and more precise than those from the original five-level wire code, though limitations in the original study remain, particularly potential control selection bias.(ABSTRACT TRUNCATED AT 250 WORDS)