Physiological Roles of GPR10 and PrRP Signaling.
Physiological Roles of GPR10 and PrRP Signaling.
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DOI：
10.3389/fendo.2013.00020
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发表时间：
2013-01-01
影响因子：
5.2
通讯作者：
Luckman, Simon M
中科院分区：
文献类型：
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作者：
Dodd, Garron T;Luckman, Simon M
催乳素释放肽（Prolactin-releasing peptide，PrRP）首先从牛下丘脑中分离得到，并被发现作为G蛋白偶联受体10（GPR 10或hGR 3）的内源性配体发挥作用。虽然最初命名为它可以影响垂体前叶细胞分泌催乳素，但在过去十年中，这种肽的潜在功能已大大扩展。解剖学、药理学和生理学研究表明，PrRP通过GPR 10受体进行信号传导，可能在神经内分泌学中具有广泛的作用;例如能量稳态、应激反应、心血管调节和昼夜节律功能。本文综述了PrRP和GPR 10信号系统的最新研究进展、功能、治疗意义以及未来展望。
Prolactin-releasing peptide (PrRP) was first isolated from bovine hypothalamus, and was found to act as an endogenous ligand at the G-protein-coupled receptor 10 (GPR10 or hGR3). Although originally named as it can affect the secretion of prolactin from anterior pituitary cells, the potential functions for this peptide have been greatly expanded over the past decade. Anatomical, pharmacological, and physiological studies indicate that PrRP, signaling via the GPR10 receptor, may have a wide range of roles in neuroendocrinology; such as in energy homeostasis, stress responses, cardiovascular regulation, and circadian function. This review will provide the current knowledge of the PrRP and GPR10 signaling system, its putative functions, implications for therapy, and future perspectives.