The developmental outcome of children with antenatal mild isolated ventriculomegaly
The developmental outcome of children with antenatal mild isolated ventriculomegaly
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DOI：
10.1016/s0029-7844(97)00112-9
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发表时间：
1997-07-01
影响因子：
7.2
通讯作者：
Twickler, DM
中科院分区：
文献类型：
--
作者：
Bloom, SL;Bloom, DD;Twickler, DM
目的：为评价超声诊断为轻度孤立性脑室扩大症的婴儿和儿童的标准化发育测试表现，对1990 ~ 1996年超声记录中的轻度孤立性脑室扩大症病例进行检索，并对患儿父母进行标准化发育测试。每个同意的孩子在性别、种族、超声适应症和超声时的胎龄（+/-2周）方面与正常产前受试者匹配。测试的认知，运动，和适应性行为，然后由考官不知情的受试者的情况下或比较status.Results：22例和相同数量的匹配的比较科目完成了测试。脑室扩大和对照组在父母年龄、母亲教育和家庭收入方面相似。脑室扩大受试者的贝利婴儿发育量表得分显著低于对照组：智力发育指数（88.95 vs 99.68，P = 0.017）和精神发育指数（95.55 vs 103.95，P = 0.039）。22名脑室扩大儿童中有8名在智力发育指数上被归类为发育迟缓，而对照组22名儿童中有1名被归类为发育迟缓（P = 0.021）。适应性行为技能，测量的葡萄园行为量表（99.64与102.68），没有显着差异组（P = .571）。结论：轻度孤立性脑室肥大产前超声检查检测与发育迟缓的显着风险。由于这些儿童在出生时被判定为完全正常，我们的研究结果代表了产前超声检查在确定儿童早期干预的目标婴儿方面的重要应用。(C)1997年由美国妇产科医师学会。
Objective: To evaluate standardized developmental test performance of infants and children who as fetuses had mild isolated cerebral ventriculomegaly diagnosed by ultrasound.Methods: Ultrasound records from 1990 to 1996 were searched for cases of mild isolated ventriculomegaly, and standardized developmental testing of the children was offered to their parents. Each consented child was matched to a normal antepartum subject with respect to sex, race, indication for ultrasound, and gestational age (+/-2 weeks) at the time of ultrasound. Tests of cognitive, motor, and adaptive behavior were then administered by examiners blinded to the subjects' case or comparison status.Results: Twenty-two cases and an equal number of matched comparison subjects completed the testing. The ventriculomegaly and comparison groups were similar with respect to parental age, maternal education, and household income. The ventriculomegaly subjects scored significantly lower than the comparison group on both the Bayley Scales of Infant Development: mental development index (88.95 versus 99.68, P = .017) and psychomotor development index (95.55 versus 103.95, P = .039). Eight of the 22 ventriculomegaly children were classified as developmentally delayed on the mental development index compared with one of 22 children in the comparison group (P = .021). Adaptive behavior skills, as measured by the Vineland Behavior Scales (99.64 versus 102.68), were not significantly different between the groups (P = .571).Conclusion: Mild isolated ventriculomegaly detected on antepartum sonographic examination is associated with a significant risk for developmental delay. Insofar as these children were judged to be completely normal at birth, our findings represent an important application of antepartum sonography for identifying infants who could be targeted for early childhood intervention. (C) 1997 by The American College of Obstetricians and Gynecologists.