Optical coherence tomography angiography for longitudinal monitoring of vascular changes in human cutaneous burns
Optical coherence tomography angiography for longitudinal monitoring of vascular changes in human cutaneous burns
复制标题
DOI：
10.1111/exd.13053
复制
发表时间：
2016-09-01
影响因子：
3.6
通讯作者：
McLaughlin, Robert A.
中科院分区：
文献类型：
--
作者：
Gong, Peijun;Es'haghian, Shaghayegh;McLaughlin, Robert A.
评估血管系统是监测皮肤烧伤愈合的一个重要方面。光学相干层析成像(OCT)的最新进展使其能够用于对活体皮肤血管系统进行高分辨率成像，有可能为传统的皮肤颜色评分提供一种更好的替代方法。本研究的目的是探讨OCT血管造影术用于皮肤烧伤患者血管系统的纵向监测和血管特征识别的可行性。我们集成了几种OCT成像协议和图像处理技术，形成了一种系统的纵向监测和自动量化方法。这种方法在部分深度烧伤上的演示显示了纵向扫描的准确定位；不同愈合阶段的特征血管特征；以及最终升高的血管面积密度和血管直径降至正常水平。这种方法有望对烧伤以及其他皮肤血管病变和治疗反应的血管系统进行纵向监测。
Assessment of vasculature is an important aspect of monitoring healing of cutaneous burn injuries. Recent advances in optical coherence tomography (OCT) have enabled it to be used to perform high-resolution imaging of the cutaneous vasculature in vivo, with the potential to provide a superior alternative to the conventional assessment of scoring skin color. The goal of this study is to investigate the feasibility of OCT angiography for longitudinal monitoring of vasculature and identification of vascular features in human cutaneous burns. We integrate several OCT imaging protocols and image-processing techniques into a systematic method for longitudinal monitoring and automatic quantification. The demonstration of this method on a partial-thickness burn shows the accurate co-location of longitudinal scans; characteristic vascular features in different healing phases; and eventual decrease of the elevated vasculature area density and vessel diameter to normal levels. Such a method holds promise for longitudinal monitoring of vasculature in burn injures as well as in other cutaneous vascular pathologies and responses to treatment.