Fat-suppressed alternating-SSFP for whole-brain fMRI using breath-hold and visual stimulus paradigms.
Fat-suppressed alternating-SSFP for whole-brain fMRI using breath-hold and visual stimulus paradigms.
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DOI：
10.1002/mrm.25797
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发表时间：
2016-05
影响因子：
3.3
通讯作者：
Bowen CV
中科院分区：
文献类型：
--
作者：
Jou T;Patterson S;Pauly JM;Bowen CV
To achieve artifact-suppressed whole-brain pass-band balanced SSFP (pb-SSFP) functional MRI from a single fMRI scan. A complete and practical data acquisition sequence for alt-SSFP fMRI was developed. First, multi-shot flyback-EPI and echo-time shifting were used to achieve data acquisition that was robust against eddy currents, gradient delays, and ghosting artifacts. Second, a steady-state catalyzation scheme was implemented to reduce oscillations in the transient signal when catalyzing in and out of alternate steady states. Next, a short spatial-spectral RF pulse was designed to achieve excellent fat-suppression while maintaining a repetition time < 15 ms to sensitize functional activation toward smaller vessels and capillaries. Lastly, parallel imaging was used to achieve whole-brain coverage and sufficiently high temporal resolution. Breath-hold experiments showed excellent fat-suppression and alt-SSFP's capability to recover functional sensitivity from signal dropout regions of conventional GRE and banding artifacts from conventional pb-SSFP. Applying fat-suppression resulted in improved activation maps and increased temporal SNR. Visual stimulus functional studies verify the proposed method's excellent functional sensitivity to neuronal activation. Artifact-suppressed images are demonstrated, showing a practical pb-SSFP fMRI method that permits whole-brain imaging with excellent BOLD sensitivity and fat suppression.
