Are oxidative stress and ischemia significant causes of bladder damage leading to lower urinary tract dysfunction? Report from the ICI-RS 2019.
Are oxidative stress and ischemia significant causes of bladder damage leading to lower urinary tract dysfunction? Report from the ICI-RS 2019.
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DOI：
10.1002/nau.24313
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发表时间：
2020-07
影响因子：
2
通讯作者：
Birder, Lori A.
中科院分区：
文献类型：
--
作者：
Speich, John E.;Tarcan, Tufan;Hashitani, Hikaru;Vahabi, Bahareh;McCloskey, Karen D.;Andersson, Karl-Erik;Wein, Alan J.;Birder, Lori A.
一些研究表明，盆腔缺血和氧化应激可能在下尿路功能障碍(LUTD)中起重要作用，包括逼尿肌过度活动(DO)/膀胱过度活动(OAB)和逼尿肌活动不足(DU)/膀胱活动不足(UAB)。本文讨论建议1：“氧化应激和缺血是导致LUTD的膀胱损伤的重要原因吗？”摘自2019年大小便失禁国际咨询研究会(ICI-RS)会议。简要描述了动物和人类的膀胱缺血，以及从缺血到LUTD的进展。将膀胱缺血与其他器官的缺血进行了比较，并对盆腔缺血动物模型的发展进行了讨论。此外，还描述了充盈和排尿过程中膀胱内的血液分布，以及活体血流量化的挑战。此外，还讨论了氧化应激，包括潜在的生物标志物和治疗方法，以及抗氧化剂治疗LUTD的挑战。最后，7个关键的研究问题和回答这些问题的拟议研究被确定为优先事项，这些优先事项将导致在理解和治疗与骨盆缺血和氧化应激相关的LUTS/LUTD方面取得重大进展。
Several studies indicate that pelvic ischemia and oxidative stress may play a significant role in lower urinary tract dysfunction (LUTD), including detrusor overactivity (DO)/overactive bladder (OAB) and detrusor underactivity (DU)/underactive bladder (UAB). The present article addresses Proposal 1: “Are oxidative stress and ischemia significant causes of bladder damage leading to LUTD?” from the 2019 International Consultation on Incontinence – Research Society (ICI-RS) meeting. Bladder ischemia in animals and humans is briefly described, along with the proposed progression from ischemia to LUTD. Bladder ischemia is compared to ischemia other organs, and the ongoing development of pelvic ischemia animal models is discussed. In addition, the distribution of blood within the bladder during filling and voiding and the challenges of quantification of blood flow in vivo are described. Furthermore, oxidative stress, including potential biomarkers and treatments, and challenges regarding antioxidant therapy for the treatment of LUTD are discussed. Finally, seven critical research questions and proposed studies to answer those questions were identified as priorities that would lead to major advances in the understanding and treatment of LUTS/LUTD associated with pelvic ischemia and oxidative stress.
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影响因子：
3.5
作者：
De, Elise J. B.;Hou, Ping;Westney, O. Lenaine
通讯作者：
Westney, O. Lenaine
影响因子：
6.6
作者：
Batista, JE;Wagner, JR;Siroky, MB
通讯作者：
Siroky, MB
DOI：
10.1016/0360-3016(94)00431-j
发表时间：
1995-03-30
影响因子：
7
作者：
MARKS, LB;CARROLL, PR;ANSCHER, MS
通讯作者：
ANSCHER, MS
影响因子：
2
作者：
de Jongh, Rik;Haenen, Guido R. M. M.;van Kerrebroeck, Philip E. V.
通讯作者：
van Kerrebroeck, Philip E. V.
影响因子：
7.4
作者：
Cadenas, E;Davies, KJA
通讯作者：
Davies, KJA