Ocular Involvement in Hospitalized Patients with Candidemia: Analysis at a Boston Tertiary Care Center
Ocular Involvement in Hospitalized Patients with Candidemia: Analysis at a Boston Tertiary Care Center
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DOI：
10.3109/09273948.2011.646383
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发表时间：
2012-04-01
影响因子：
3.3
通讯作者：
Borboli-Gerogiannis, Sheila
中科院分区：
文献类型：
--
作者：
Huynh, Nancy;Chang, Han-Ying Peggy;Borboli-Gerogiannis, Sheila
目的：研究念珠菌感染患者眼部受累的患病率、微生物特征和危险因素。方法：回顾性分析2009年10月至2011年6月在布莱根妇女医院（Brigham and Women's Hospital）为评估念珠菌病患者眼部受累情况而要求的所有住院会诊记录。结果：49名会诊者被要求排除念珠菌病患者的眼部受累。患者平均年龄为55岁。从频率上看，分离出的念珠菌依次为白色念珠菌（42%）、假丝酵母菌（23%）、光秃念珠菌（17%）、热带念珠菌（8%）、都柏林念珠菌（5%）、克鲁氏念珠菌（3%）和卢西念珠菌（3%）。所有患者在初次眼科检查时均接受抗真菌治疗。1例患者有脉络膜视网膜炎的证据，3例患者有非特异性眼底发现。常见的危险因素包括静脉留置、恶性肿瘤和腹部手术。结论：眼部受累在全身性念珠菌感染患者中是罕见的。
Purpose: To study the prevalence, microbial profile, and risk factors for ocular involvement in patients with candidemia.Methods: The records of all inpatient consultations requested at the Brigham and Women's Hospital from October 2009 to June 2011 to evaluate for ocular involvement in patients with candidemia were retrospectively reviewed.Results: Forty-nine consults were requested to rule out ocular involvement in patients with candidemia. The mean patient age was 55 years. In decreasing frequency, the organisms isolated were Candida albicans (42%), Candida parapsilosis (23%), Candida glabrata (17%), Candida tropicalis (8%), Candida dublinensis (5%), Candida krusei (3%), and Candida lusitaniae (3%). All patients were on antifungal treatment at the time of their initial ophthalmologic examination. One patient had evidence of chorioretinitis, and 3 patients had nonspecific fundus findings. Common risk factors included presence of an intravenous catheter, malignancy, and abdominal surgery.Conclusions: Ocular involvement is rare among patients with systemic Candida infection.