Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury.
Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury.
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时间上不同的髓细胞反应介导脑血管损伤后的损伤和修复。
DOI：
10.1038/s41593-020-00773-6
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发表时间：
2021-03
影响因子：
25
通讯作者：
McGavern DB
中科院分区：
文献类型：
--
作者：
Mastorakos P;Mihelson N;Luby M;Burks SR;Johnson K;Hsia AW;Witko J;Frank JA;Latour L;McGavern DB
Cerebrovascular injuries can cause severe edema and inflammation that adversely affect human health. Here, we observed recanalization after successful endovascular thrombectomy for acute large vessel occlusion was associated with cerebral edema and poor clinical outcomes in patients who experienced hemorrhagic transformation. To understand this process, we developed a cerebrovascular injury model using transcranial ultrasound that enabled spatiotemporal evaluation of resident and peripheral myeloid cells. We discovered that injurious and reparative responses diverged based on time and cellular origin. Resident microglia initially stabilized damaged vessels in a purinergic receptor-dependent manner, which was followed by influx of myelomonocytic cells that caused severe edema. Prolonged blockade of myeloid cell recruitment with anti-adhesion molecule therapy prevented severe edema but also promoted neuronal destruction and fibrosis by interfering with vascular repair later orchestrated by pro-inflammatory monocytes and pro-angiogenic repair-associated microglia (RAM). These data demonstrate how temporally distinct myeloid cell responses can contain, exacerbate, and ultimately repair a cerebrovascular injury.
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影响因子：
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作者：
Kim, Jiyun V.;Kang, Silvia S.;Dustin, Michael L.;McGavern, Dorian B.
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