Multiscale Modeling of Circular and Elliptical Particles in Laminar Shear Flow
Multiscale Modeling of Circular and Elliptical Particles in Laminar Shear Flow
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DOI：
10.1109/tbme.2011.2166264
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发表时间：
2012-01-01
影响因子：
4.6
通讯作者：
Kojic, Milos
中科院分区：
文献类型：
--
作者：
Filipovic, Nenad;Isailovic, Velibor;Kojic, Milos
用于癌症预防和疼痛管理的药物递送系统已经相对于经典的癌症化学疗法得到改进。具有纳米颗粒的纳米技术提供了通过血液流动通过循环系统运输药物分子和造影剂的新方法。在这项研究中，我们使用多尺度介观桥接程序的有限元（FE）耦合耗散粒子动力学（DPD）和格子Boltzmann（LB）方法模拟二维层流中的圆形和椭圆形颗粒的运动。考虑了四个例子：1）通道中的一个沉降圆柱体，2）通道中的两个沉降圆柱体，3）线性剪切流中的四个椭圆形颗粒的运动，以及4）动脉分叉几何形状中的圆形和椭圆形颗粒的运动。这些结果表明，耦合FE和DPD/LB方法的多尺度方法可以有效地应用于药物输送系统中微/纳米颗粒的运动模型。
Drug delivery systems for cancer prevention and pain management have been improved related to classical cancer chemotherapy. Nanotechnology with nanoparticles offers new ways in transport of drug molecules and contrast agents by the blood flow through the circulatory system. In this study, we use multiscale mesoscopic bridging procedure of the finite elements (FE) coupled with dissipative particle dynamics (DPD) and lattice Boltzmann (LB) method to model the motion of circular and elliptical particles in a 2-D laminar flow. Four examples are considered: 1) one sedimenting cylinder in a channel, 2) two sedimenting cylinders in a channel, 3) motion of four elliptical particles in a linear shear flow, and 4) motion of circular and elliptical particle in the arterial bifurcation geometry. A good agreement with solution from the literature available was found. These results show that the multiscale approach with coupled FE and DPD/LB methods can effectively be applied to model motion of micro/nanoparticles for a drug delivery system.