Evaluation of Quadrox-i® Adult Hollow Fiber Oxygenator with Integrated Arterial Filter
Evaluation of Quadrox-i® Adult Hollow Fiber Oxygenator with Integrated Arterial Filter
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带集成动脉过滤器的 Quadrox-i® 成人中空纤维氧合器的评估
DOI：
10.1051/ject/201042134
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
A. Ündar
中科院分区：
文献类型：
--
作者：
Y. Guan;Xiaowei W Su;Robert M McCoach;R. Wise;A. Kunselman;A. Ündar
气态微栓子（GME）仍然是成人和小儿心脏手术患者心肺转流手术的一个挑战。本研究在有和没有集成动脉过滤器的模型中测试了新型成人膜式氧合器的有效性，以评价GME捕获能力并确定不同流速和温度下的膜压降。实验回路包括RotaFlow离心血泵、Quadrox-i®（n = 8）或Quadrox®（n = 8）成人微孔膜式氧合器和Sorin成人管路包。Sorin Cardiovascular® VVR® 4000 i静脉储血器用作假患者。用900 mL肝素化人红细胞和300 mL乳酸林格氏溶液预充回路。最终红细胞压积为36%。在不同流速（4 L/min、5 L/min和6 L/min）和温度（35°和30°）下进行测试。使用连接到3/8 × 1/2鲁尔接头的注射器在15秒内将5 mL推注空气注入静脉管路。与Quadrox®膜式氧合器相比，配备集成动脉滤器的Quadrox-i®成人微孔膜式氧合器在4 L/min和35°C下的压降相似，但在5 L/min和6 L/min下的压降更高（p <.001）。Quadrox-i®成人微孔膜式氧合器在所有流速下均减少了输送至假患者的总栓子计数和总栓子体积（p <0.001）。Quadrox-i®成人微孔膜式氧合器的栓子处理不受流速和温度的影响。与传统的Quadrox®氧合器相比，Quadrox-i®成人微孔膜式氧合器集成了动脉过滤器和Softline涂层，提高了GME处理能力。
Gaseous microemboli (GME) remain a challenge for cardiopulmonary bypass procedures in adult as well as pediatric cardiac surgery patients. The present study tested the effectiveness of a new adult membrane oxygenator in models both with and without an integrated arterial filter to evaluate GME trapping capability and determine membrane pressure drops at various flow rates and temperatures. The experimental circuit included a RotaFlow centrifugal blood pump, Quadrox-i® (n = 8) or Quadrox® (n = 8) adult microporous membrane oxygenator, and Sorin adult tubing package. A Sorin Cardiovascular® VVR® 4000i venous reservoir served as pseudo-patient. The circuit was primed with 900 mL heparinized human red blood cells and 300 mL Lactated Ringer’s solution. The final hematocrit was 36%. Tests were performed at different flow rates (4 L/min, 5 L/min, and 6 L/min) and temperatures (35° and 30°). Five mL of bolus air was injected into the venous line over 15 seconds using a syringe connected to a 3/8 × 1/2 luer connector. The Quadrox-i® adult microporous membrane oxygenator with integrated arterial filter had a similar pressure drop at 4 L/min and 35°C compared with Quadrox® membrane oxygenator whereas it had higher pressure drops at 5 L/min and 6 L/min (p <.001). Quadrox-i® adult microporous membrane oxygenator reduced the total emboli count and total emboli volume delivered to the pseudo-patient at all flow rates (p <.001). The emboli handling of Quadrox-i® adult microporous membrane oxygenator was not affected by flow rate and temperature. Compared with the traditional Quadrox® oxygenator, Quadrox-i® adult microporous membrane oxygenator with integrated arterial filter and Softline coating has improved GME handling capacity.