A comparison of the effects of timolol and epinephrine on intraocular pressure.
A comparison of the effects of timolol and epinephrine on intraocular pressure.
复制标题
噻吗洛尔和肾上腺素对眼压影响的比较。
DOI：
10.1016/0002-9394(78)90294-5
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发表时间：
1978
影响因子：
4.2
通讯作者：
S. Podos
中科院分区：
文献类型：
--
作者：
A. Moss;R. Ritch;N. Hargett;A. Kohn;H. Smith;S. Podos
自1967年发现口服普萘洛尔可降低眼内压以来，β-肾上腺素能受体阻滞剂的眼部扩张特性已得到认可。1随后的研究表明，类似的药物，如氧烯洛尔，2吲哚洛尔，3阿替洛尔，4_6和普拉洛尔7，无论是全身或局部给药时，都能有效降低眼内压。然而，其中一些药物与严重的不良副作用有关。8-14马来酸噻吗洛尔是另一种β-肾上腺素能阻断药，具有显著的眼部肿胀作用，无明显的眼部或全身副作用。15-21噻吗洛尔降低正常血压患者的眼内压15，与安慰剂相比，降低开角型青光眼患者的眼内压17'18。短期研究18证明，0.5%噻吗洛尔溶液处于剂量-反应曲线的峰值。在该浓度下，观察到眼部肿胀效应持续24小时或更长时间。机甲-
The ocular hypotensive properties of the beta-adrenergic blocking agents have been recognized since 1967, when it was noted that oral propranolol decreased the intraocular pressure. 1 Subsequent studies showed similar agents, such as oxprenolol, 2pindolol, 3atenolol, 4_6andpractolol7to be effective in decreasing intraocular pressure when administered either systemically or topically. Some of these drugs, however, have been associated with severe adverse side effects. 8-14 Timolol maleate, another beta-ad renergic blocking drug, has shown im pressive ocular hypotensive effects with out significant ocular or systemic side effects. 15-21 Timolol decreased intraocular pressure both in normotensive patients15 and, as compared to a placebo, 17'18 in patients with open-angle glaucoma. Short-term studies18 have demonstrated that 0.5% timolol solution is at the peak of the dose-response curve. At this concen tration, ocular hypotensive effects were noted for 24 hours or longer. The mecha-