Role of iNOS in osteoarthritis: Pathological and therapeutic aspects.
Role of iNOS in osteoarthritis: Pathological and therapeutic aspects.
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DOI：
10.1002/jcp.29607
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发表时间：
2020-10
影响因子：
5.6
通讯作者：
Haqqi TM
中科院分区：
文献类型：
--
作者：
Ahmad N;Ansari MY;Haqqi TM
越来越多的证据表明，炎症在骨关节炎（OA）的发病机制中起着关键作用。一氧化氮（NO）是OA的主要炎症介质之一，并在OA的发生和发展过程中驱动许多病理变化。软骨细胞中NO的过量产生促进软骨破坏和细胞损伤。软骨细胞中NO的合成由诱导型一氧化氮合酶（iNOS）催化，因此其是治疗OA的有吸引力的治疗靶点。许多直接和间接的iNOS抑制剂、生物活性化合物和植物来源的小分子已被证明通过抑制iNOS的表达而表现出软骨保护作用。这些iNOS抑制剂中有许多有望开发新的OA疾病修饰疗法;然而，尚未实现在临床试验中证明其成功的尝试。许多植物提取物和植物衍生的小分子在OA动物模型中也显示出了希望，尽管需要在人体临床试验中进行进一步的研究以确认其治疗潜力。在这篇综述中，我们讨论了iNOS在OA病理中的作用以及各种iNOS抑制剂在OA中的作用。
Accumulating evidence suggests that inflammation has a key role in the pathogenesis of Osteoarthritis (OA). Nitric oxide (NO) is established as one of the major inflammatory mediators in OA and drives many pathological changes during the development and progression of OA. Excessive production of NO in chondrocyte promotes cartilage destruction and cellular injury. Synthesis of NO in chondrocytes is catalyzed by inducible nitric oxide synthase (iNOS), which is thereby an attractive therapeutic target for the treatment of OA. A number of direct and indirect iNOS inhibitors, bioactive compounds, and plant-derived small molecules have been shown to exhibit chondroprotective effect by suppressing the expression of iNOS. Many of these iNOS inhibitors hold promise for the development of new, disease-modifying therapies for OA; however, attempts to demonstrate their success in clinical trials is not yet achieved. Many plant extracts and plant-derived small molecules have also shown promise in animal models of OA, though further studies are needed in human clinical trials to confirm their therapeutic potential. In this review, we discuss the role of iNOS in OA pathology and the effects of various iNOS inhibitors in OA.
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影响因子：
3.3
作者：
Sophia Fox AJ;Bedi A;Rodeo SA
通讯作者：
Rodeo SA
影响因子：
7
作者：
Abramson, Steven B.
通讯作者：
Abramson, Steven B.
影响因子：
--
作者：
Akhtar N;Miller MJ;Haqqi TM
通讯作者：
Haqqi TM
DOI：
10.1084/jem.182.6.2097
发表时间：
1995-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Amin AR;Di Cesare PE;Vyas P;Attur M;Tzeng E;Billiar TR;Stuchin SA;Abramson SB
通讯作者：
Abramson SB
影响因子：
--
作者：
Clements, KM;Price, JS;Mason, RM
通讯作者：
Mason, RM