Brief Report: Increased Cotinine Concentrations are Associated With Reduced Expression of Cathelicidin (LL-37) and NOD-2 in Alveolar Macrophages of PLWH Who Smoke.
Brief Report: Increased Cotinine Concentrations are Associated With Reduced Expression of Cathelicidin (LL-37) and NOD-2 in Alveolar Macrophages of PLWH Who Smoke.
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DOI：
10.1097/qai.0000000000002491
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发表时间：
2020-12-15
期刊：
影响因子：
--
通讯作者：
Wewers M
中科院分区：
文献类型：
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作者：
Diaz PT;Ferketich A;Wewers ME;Browning K;Gavrilin MA;Sarkar A;Hollyfield J;Trinka T;Wewers M
吸烟与艾滋病毒感染者的肺部并发症之间有着密切的联系。然而，吸烟对该人群局部肺免疫环境的影响尚不清楚。支气管肺泡灌洗液和唾液收集自HIV感染的吸烟者，这些吸烟者参与了一项前瞻性研究，该研究调查了宿主防御分子的肺泡巨噬细胞表达。唾液可替宁浓度与免疫细胞受体NOD-2和凯萨林菌素抗菌肽LL-37的表达呈负相关。唾液可替宁和LL-37之间的负相关性特别强。我们的研究提供了关于尼古丁如何对HIV患者的肺部先天免疫产生不利影响的见解。
There is a strong link between cigarette smoking and pulmonary complications among people living with HIV. However, the effects of smoking on the local lung immune environment in this population remain unclear. Bronchoalveolar lavage and saliva were collected from HIV-infected smokers involved in a prospective study investigating alveolar macrophage expression of host defense molecules. Salivary cotinine concentrations were inversely related to expression of the immune cell receptor NOD-2 and the cathelicidin antimicrobial peptide LL-37. The negative correlation between salivary cotinine and LL-37 was particularly strong. Our study provides insight into how nicotine may adversely affect lung innate immunity in HIV.