Natural selection among Eurasians at genomic regions associated with HIV-1 control.
Natural selection among Eurasians at genomic regions associated with HIV-1 control.
复制标题
与HIV-1控制相关的基因组区域的欧亚人的自然选择。
DOI：
10.1186/1471-2148-11-173
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发表时间：
2011-06-20
影响因子：
3.4
通讯作者：
Shrestha S
中科院分区：
文献类型：
--
作者：
Klimentidis YC;Aissani B;Shriver MD;Allison DB;Shrestha S
HIV susceptibility and pathogenicity exhibit both interindividual and intergroup variability. The etiology of intergroup variability is still poorly understood, and could be partly linked to genetic differences among racial/ethnic groups. These genetic differences may be traceable to different regimes of natural selection in the 60,000 years since the human radiation out of Africa. Here, we examine population differentiation and haplotype patterns at several loci identified through genome-wide association studies on HIV-1 control, as determined by viral-load setpoint, in European and African-American populations. We use genome-wide data from the Human Genome Diversity Project, consisting of 53 world-wide populations, to compare measures of FST and relative extended haplotype homozygosity (REHH) at these candidate loci to the rest of the respective chromosome. We find that the Europe-Middle East and Europe-South Asia pairwise FST in the most strongly associated region are elevated compared to most pairwise comparisons with the sub-Saharan African group, which exhibit very low FST. We also find genetic signatures of recent positive selection (higher REHH) at these associated regions among all groups except for sub-Saharan Africans and Native Americans. This pattern is consistent with one in which genetic differentiation, possibly due to diversifying/positive selection, occurred at these loci among Eurasians. These findings are concordant with those from earlier studies suggesting recent evolutionary change at immunity-related genomic regions among Europeans, and shed light on the potential genetic and evolutionary origin of population differences in HIV-1 control.
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影响因子：
10.7
作者：
Ortiz, Millan;Guex, Nicolas;Telenti, Amalio
通讯作者：
Telenti, Amalio
影响因子：
3.8
作者：
Shrestha, Sadeep;Aissani, Brahim;Tang, Jianming
通讯作者：
Tang, Jianming
DOI：
10.1098/rspb.2009.2073
发表时间：
2010-07-07
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Cromer D;Wolinsky SM;McLean AR
通讯作者：
McLean AR
影响因子：
7
作者：
Pickrell, Joseph K.;Coop, Graham;Pritchard, Jonathan K.
通讯作者：
Pritchard, Jonathan K.
影响因子：
10.7
作者：
Kudaravalli S;Veyrieras JB;Stranger BE;Dermitzakis ET;Pritchard JK
通讯作者：
Pritchard JK