Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man
Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man
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DOI：
10.1002/mrm.1910350202
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发表时间：
1996-02-01
影响因子：
3.3
通讯作者：
Kleinschmidt, A
中科院分区：
文献类型：
--
作者：
Frahm, J;Kruger, G;Kleinschmidt, A
使用动态磁共振波谱和成像测量了在人初级视皮层中延长的神经元激活（4-6分钟）期间葡萄糖消耗、乳酸产生和血氧的变化。由于增强使用21%，稳态葡萄糖减少40%，伴随着乳酸的瞬时积累，在刺激开始后2.5分钟峰值为170%，表明血流和氧化代谢“解偶联”的快速血液高氧合之后，在3分钟内恢复到基础水平。因此，功能激活期间的初始非氧化葡萄糖消耗逐渐由氧化磷酸化的较慢调节补充，氧化磷酸化在新的平衡下“重新偶联”灌注和氧消耗。
Changes in glucose consumption, lactate production, and blood oxygenation were measured during prolonged neuronal activation (4-6 min) in human primary visual cortex using dynamic magnetic resonance spectroscopy and imaging, A decrease of steady-state glucose by 40% because of enhanced use by 21% was accompanied by a transient accumulation of lactate with a peak value of 170% 2.5 min after stimulation onset, Rapid blood hyperoxygenation indicating ''uncoupling'' of blood flow and oxidative metabolism was followed by a return to basal levels over 3 min, Thus, initial nonoxidative glucose consumption during functional activation is gradually complemented by a slower adjustment of oxidative phosphorylation that ''recouples'' perfusion and oxygen consumption at a new equilibrium.