SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.
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DOI：
10.1172/jci15593
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发表时间：
2002-05
期刊：
影响因子：
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通讯作者：
J. Horton;J. Goldstein;Michael S. Brown
中科院分区：
文献类型：
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作者：
J. Horton;J. Goldstein;Michael S. Brown
脊椎动物细胞中的脂质平衡由一组膜结合的转录因子调节，该转录因子被称为固醇调节元件结合蛋白(SREBPs)。SREBPs直接激活30多个与胆固醇、脂肪酸、甘油三酯和磷脂的合成和吸收有关的基因的表达，以及合成这些分子所需的NADPH辅助因子(1-4)。在肝脏中，三种SREBPs调节脂质的产生，以脂蛋白的形式输出到血浆中，并以胶束的形式输出到胆汁中。通过对10个不同品系的基因操纵小鼠的研究，对这三个SREBPs复杂的、交错的作用进行了剖析。这些研究构成了本综述的主题。
Lipid homeostasis in vertebrate cells is regulated by a family of membrane-bound transcription factors designated sterol regulatory element–binding proteins (SREBPs). SREBPs directly activate the expression of more than 30 genes dedicated to the synthesis and uptake of cholesterol, fatty acids, triglycerides, and phospholipids, as well as the NADPH cofactor required to synthesize these molecules (1–4). In the liver, three SREBPs regulate the production of lipids for export into the plasma as lipoproteins and into the bile as micelles. The complex, interdigitated roles of these three SREBPs have been dissected through the study of ten different lines of gene-manipulated mice. These studies form the subject of this review.