Plasma detection of NO by a catheter
Plasma detection of NO by a catheter
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DOI：
10.1007/s11517-008-0333-z
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发表时间：
2008-05-01
影响因子：
3.2
通讯作者：
Mochizuki, Seiichi
中科院分区：
文献类型：
--
作者：
Goto, Masami;Mochizuki, Seiichi
内皮细胞在血流动力学切应力作用下释放的一氧化氮（NO）是血管功能和抗动脉粥样硬化机制的关键控制分子。内皮功能障碍与心血管事件增加相关。因此，一些间接技术已被用来评估内皮功能或NO生物利用度。然而，越来越多的证据表明，间接方法用于评估NO生物利用度的局限性。多年来，人们一直认为NO在血流中被立即氧化或失活。然而，最近的研究表明，NO在血流中保持活性，引起远程生物反应。因此，直接测量循环中的血浆NO浓度将有助于阐明NO的动力学和生理作用，并评估内皮功能。在这篇文章中，将描述使用新开发的导管型NO传感器测量血浆NO浓度。
Nitric oxide (NO) released by endothelial cells in response to hemodynamic shear stress is a key controller molecule of the vascular functions and antiatherogenic mechanisms. Endothelial dysfunction is associated with increased cardiovascular events. Therefore, several indirect techniques have been employed to evaluate endothelial function or NO bioavailability. However, a growing body of evidences suggests limitations of the indirect methods for evaluation of NO bioavailability. In years, it has been considered that NO is immediately oxidized or inactivated in blood stream. However, recent studies suggest that NO remain active in blood stream, causing remote biological response. Therefore, measuring plasma NO concentration directly in the circulation will contribute to clarify the kinetics and physiological roles of NO and to evaluate endothelial function. In this article, the measurement of plasma NO concentration using a newly developed catheter-type NO sensor will be described.