Impairment of hippocampal neurogenesis in streptozotocin‐treated diabetic rats
Impairment of hippocampal neurogenesis in streptozotocin‐treated diabetic rats
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DOI：
10.1111/j.1600-0404.2007.00928.x
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发表时间：
2008-03
影响因子：
3.5
通讯作者：
W. Zhang;Y.-F. Tan;J. Yue;M. Vranic;J. Wojtowicz
中科院分区：
文献类型：
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作者：
W. Zhang;Y.-F. Tan;J. Yue;M. Vranic;J. Wojtowicz
Objectives – Adult neurogenesis in dentate gyrus (DG) is an evolutionarily preserved trait in most mammals examined thus far. Neuronal proliferation and subsequent integration of new neurons into the hippocampal circuit are regulated processes that can have profound effects on an animal’s behaviour. A streptozotocin model of type I diabetes, characterized by low insulin and high plasma glucose levels, affects not only body’s overall metabolism but also brain activity.
