Specialized Pro-Resolving Mediators as Potential Regulators of Inflammatory Macrophage Responses in COVID-19.
Specialized Pro-Resolving Mediators as Potential Regulators of Inflammatory Macrophage Responses in COVID-19.
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专门的促消退介体作为COVID-19中炎症巨噬细胞反应的潜在调节剂。
DOI：
10.3389/fimmu.2021.632238
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发表时间：
2021
影响因子：
7.3
通讯作者：
Christopoulos PF
中科院分区：
文献类型：
--
作者：
Balta MG;Papathanasiou E;Christopoulos PF
最近爆发的SARS-CoV 2已成为我们世纪最大的流行病之一，在全球范围内造成了严重的健康、社会和经济后果。巨噬细胞可能是COVID-19发病机制和致死性的中心，治疗巨噬细胞诱导的细胞因子风暴已成为必不可少的。专门的促消退介质（SPM）在COVID-19的治疗中具有强大的治疗潜力，因为它们可以调节巨噬细胞浸润和细胞因子产生，同时也促进促消退巨噬细胞表型。在这篇综述中，我们讨论了稳态功能的SPM直接作用于巨噬细胞在各个层面上，对炎症的决议。此外，我们讨论了将脂质介质与COVID-19严重程度联系起来的分子事件，并讨论了SPM在COVID-19免疫治疗中的临床潜力。
The recent outbreak of SARS-CoV2 has emerged as one of the biggest pandemics of our century, with outrageous health, social and economic consequences globally. Macrophages may lay in the center of COVID-19 pathogenesis and lethality and treatment of the macrophage-induced cytokine storm has emerged as essential. Specialized pro-resolving mediators (SPMs) hold strong therapeutic potentials in the management of COVID-19 as they can regulate macrophage infiltration and cytokine production but also promote a pro-resolving macrophage phenotype. In this review, we discuss the homeostatic functions of SPMs acting directly on macrophages on various levels, towards the resolution of inflammation. Moreover, we address the molecular events that link the lipid mediators with COVID-19 severity and discuss the clinical potentials of SPMs in COVID-19 immunotherapeutics.
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影响因子：
4.6
作者：
Arcanjo A;Logullo J;Menezes CCB;de Souza Carvalho Giangiarulo TC;Dos Reis MC;de Castro GMM;da Silva Fontes Y;Todeschini AR;Freire-de-Lima L;Decoté-Ricardo D;Ferreira-Pereira A;Freire-de-Lima CG;Barroso SPC;Takiya C;Conceição-Silva F;Savino W;Morrot A
通讯作者：
Morrot A
影响因子：
6
作者：
de la Rosa, Xavier;Norris, Paul C.;Serhan, Charles N.
通讯作者：
Serhan, Charles N.
DOI：
10.1073/pnas.0405445101
发表时间：
2004-10-19
影响因子：
11.1
作者：
Chiang, N;Bermudez, EA;Serhan, CN
通讯作者：
Serhan, CN
影响因子：
46.9
作者：
Chua, Robert Lorenz;Lukassen, Soeren;Eils, Roland
通讯作者：
Eils, Roland
影响因子：
16.6
作者：
Fredman, Gabrielle;Hellmann, Jason;Proto, Jonathan D.;Kuriakose, George;Colas, Romain A.;Dorweiler, Bernhard;Connolly, E. Sander;Solomon, Robert;Jones, David M.;Heyer, Eric J.;Spite, Matthew;Tabas, Ira
通讯作者：
Tabas, Ira