DIPHTHERIA-TETANUS-PERTUSSIS IMMUNIZATION AND SUDDEN-INFANT-DEATH-SYNDROME
DIPHTHERIA-TETANUS-PERTUSSIS IMMUNIZATION AND SUDDEN-INFANT-DEATH-SYNDROME
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DOI：
10.2105/ajph.77.8.945
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发表时间：
1987-08-01
影响因子：
12.7
通讯作者：
KNAUSS, TA
中科院分区：
文献类型：
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作者：
WALKER, AM;JICK, H;KNAUSS, TA
我们采用改良的病例对照分析，比较了出生体重大于2500 g死于婴儿猝死综合征（SIDS）的健康儿童与年龄匹配的参考儿童的白喉-破伤风-百日咳（DTP）免疫接种的近期情况。我们把注意力集中在接种疫苗后很短的时间间隔上，发现接种白喉、破伤风和百日咳疫苗后0至3天内的小岛屿发展中国家死亡率是接种疫苗后30天内的7.3倍（95%置信区间为1.7至31）。未接种疫苗婴儿的死亡率是同龄接种疫苗婴儿的6.5倍（95%置信区间，2.2至19）。后一种结果以及在某种程度上前一种结果似乎可归因于已知的小岛屿发展中国家风险因素。尽管根据本研究的估计，DTP后SIDS的死亡率很高，但明显升高的风险期很短，因此出生体重大于2500 g的婴儿中只有一小部分SIDS病例与DTP相关。
We compared the recency of diphtheria-tetanus-pertussis (DTP) immunization in healthy children with birthweights greater than 2500 gms who died of sudden infant death syndrome (SIDS) to that of age-matched reference children, using a modified case-control analysis. Focusing on very narrow time intervals following immunization, we found the SIDS mortality rate in the period zero to three days following DTP to be 7.3 times that in the period beginning 30 days after immunization (95 per cent confidence interval, 1.7 to 31). The mortality rate of non-immunized infants was 6.5 times that of immunized infants of the same age (95 per cent CI, 2.2 to 19). The latter result and to some extent the former appear to be ascribable to known risk factors for SIDS. Although the mortality ratios for SIDS follow DTP, as estimated from this study, are high the period of apparently elevated risk was very short, so that only a small proportion of SIDS cases in infants with birthweights greater than 2500 gms could be associated with DTP.