SOME OBSERVATIONS ON THE PATHOGENESIS AND NATURAL HISTORY OF INTRACRANIAL ANEURYSMS
SOME OBSERVATIONS ON THE PATHOGENESIS AND NATURAL HISTORY OF INTRACRANIAL ANEURYSMS
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DOI：
10.1136/jnnp.22.4.259
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发表时间：
1959-01-01
影响因子：
11
通讯作者：
CRAWFORD, T
中科院分区：
文献类型：
--
作者：
CRAWFORD, T
基于对 163 个破裂脑动脉瘤和 40 个未破裂脑动脉瘤的解剖，介绍了颅内动脉瘤的发展、生长和随后的破裂。动脉瘤从威利斯环的动脉交界处之一发展而来，在 1/8 的病例中本质上是多发性的，并且随着它们的生长可能会包裹邻近的血管和神经和/或变成双眼的。直径为 6-15 毫米时，它们可能会产生临床效果，有些会模拟肿瘤。至少 64% 的病例破裂发生在动脉瘤底部。脑动脉由于中层较薄且发育不良甚至缺乏外弹力层，因此更容易发生动脉瘤。与其发生相关的其他因素包括介质发育缺陷、血压变化和动脉粥样硬化。
An account of the development, growth and subsequent rupture of intracranial aneurysms based upon the dissection of 163 ruptured and 40 unruptured cerebral aneurysms is presented. The aneurysms develop from one of the arterial junctions of the circle of Willis, are multiple in nature in 1/8 of the cases and may wrap around adjacent vessels and nerves and/or become bilocular as they grow. At a diameter of 6-15 mm they may produce clinical effects, some simulating tumors. Rupture occurs at the fundus of the aneurysm in at least 64% of the cases. Cerebral arteries are more prone to aneurysms due to a thinner media and a poorly developed to absent external elastic lamina. Other factors related to their occurrence are developmental faults in the media, blood pressure changes and atherosclerosis.