Exercise Pathophysiology in Patients With Chronic Mountain Sickness
Exercise Pathophysiology in Patients With Chronic Mountain Sickness
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DOI：
10.1378/chest.11-2845
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发表时间：
2012-10-01
期刊：
影响因子：
9.6
通讯作者：
Naeije, Robert
中科院分区：
文献类型：
--
作者：
Groepenhoff, Herman;Overbeek, Marieke J.;Naeije, Robert
背景资料：慢性高山病（CMS）的特点是过度红细胞增多症，严重低氧血症，肺动脉高压，所有这些都影响运动能力的组合。方法：13例CMS和15名健康的高地人和15名新人低地人对照组在海拔4,350米（塞罗德帕斯科，秘鲁）进行了调查。所有受试者均接受了静息时肺一氧化氮和一氧化碳弥散量的测量，超声心动图评估静息和运动时的平均肺动脉压和心输出量，以及递增式踏车运动心肺功能试验。CMS患者、健康的高地人和新来的低地人达到了相似的最大摄氧量，分别为32 +/-1、32 +/-2，和33 +/-2 mL/min/kg，平均+/-SE（P =.8），在无氧阈值下测量的CO2与潮气末P-CO2的解释当量分别为0.9 +/-0.1、1.2 +/-0.1和1.4 +/-0.1 mmHg（P
Background: Chronic mountain sickness (CMS) is characterized by a combination of excessive erythrocytosis, severe hypoxemia, and pulmonary hypertension, all of which affect exercise capacity.Methods: Thirteen patients with CMS and 15 healthy highlander and 15 newcomer lowlander control subjects were investigated at an altitude of 4,350 m (Cerro de Pasco, Peru). All of them underwent measurements of diffusing capacity of lung for nitric oxide and carbon monoxide at rest, echocardiography for estimation of mean pulmonary arterial pressure and cardiac output at rest and at exercise, and an incremental cycle ergometer cardiopulmonary exercise test.Results: The patients with CMS, the healthy highlanders, and the newcomer lowlanders reached a similar maximal oxygen uptake at 32 +/- 1, 32 +/- 2, and 33 +/- 2 mL/min/kg, respectively, mean +/- SE (P = .8), with ventilatory equivalents for CO2 vs end-tidal P-CO2, measured at the anaerobic threshold, of 0.9 +/- 0.1, 1.2 +/- 0.1, and 1.4 +/- 0.1 mm Hg, respectively (P