The somatotopic organization of cytoarchitectonic areas on the human parietal operculum
The somatotopic organization of cytoarchitectonic areas on the human parietal operculum
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DOI：
10.1093/cercor/bhl090
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发表时间：
2007-08-01
期刊：
影响因子：
3.7
通讯作者：
Fink, Gereon R.
中科院分区：
文献类型：
--
作者：
Eickhoff, Simon B.;Grefkes, Christian;Fink, Gereon R.
非人类灵长类动物的次级体感皮层（SII）位于顶叶盖上。在猴子中，电生理学和连通性追踪研究以及组织学研究为该区域内 3 个不同的皮质区域（SII、PV 和 VS）提供了聚合证据，每个区域都包含完整的体位图。尽管顶叶盖作为人类和非人类灵长类动物的 SII 位置的等同性是无可争议的，但人类 SII 区域的内部组织仍然很大程度上未知。根据它们的拓扑结构，我们之前认为细胞结构区域 OP 1、OP 4 和 OP 3 可能分别构成人类 SII、PV 和 VS 区域的同源物。为了检验这一假设，我们通过对身体两侧（面部、手部、躯干和腿部）4 个不同位置的皮肤施加触觉刺激，检查（使用功能性磁共振成像）人类顶叶盖的体位组织。然后将所得激活灶的位置与该区域的细胞结构图进行比较。数据分析揭示了 OP 1 和 OP 4 区域的侧盖上的 2 个体位身体表征。这 2 个身体图之间的功能边界是通过体位排列中的镜像反转来定义的，并且与这两个区域之间的细胞结构定义的边界一致。这种体位排列与非人类灵长类动物中 SII 和 PV 的描述非常匹配。数据还表明，第三个体位图位于外侧裂内部更深处的 OP 3 区域。根据观察到的地形排列及其功能响应特征，我们得出结论，人类顶盖上的细胞结构区域 OP1、OP 4 和 OP 3 分别构成灵长类动物区域 SII、PV 和 VS 的人类同源物。 11
The secondary somatosensory cortex (SII) of nonhuman primates is located on the parietal operculum. In the monkey, electrophysiological and connectivity tracing studies as well as histological investigations provide converging evidence for 3 distinct cortical areas (SII, PV, and VS) within this region, each of which contains a complete somatotopic map. Although the equivalency of the parietal operculum as the location of SII between humans and nonhuman primates is undisputed, the internal organization of the human SII region is still largely unknown. Based on their topography, we have previously argued that the cytoarchitectonic areas OP 1, OP 4, and OP 3 may constitute the human homologues of areas SII, PV, and VS, respectively. To test this hypothesis, we here examined (using functional magnetic resonance imaging) the somatotopic organization of the human parietal operculum by applying tactile stimulation to the skin at 4 different locations on either side of the body (face, hands, trunk, and legs). The locations of the resulting activation foci were then compared with the cytoarchitectonic maps of this region. Data analysis revealed 2 somatotopic body representations on the lateral operculum in areas OP 1 and OP 4. The functional border between these 2 body maps was defined by a mirror reversal in the somatotopic arrangement and coincided with the cytoarchitectonically defined border between these 2 areas. This somatotopic arrangement closely matches that described for SII and PV in nonhuman primates. The data also suggested a third somatotopic map located deeper inside the Sylvian fissure in area OP 3. Based on the observed topographic arrangement and their functional response characteristics, we conclude that cyloarchitectonic areas OP1, OP 4, and OP 3 on the human parietal operculum constitute the human homologues of primate areas SII, PV, and VS, respectively. 11