Energetic ultrafast fiber laser sources tunable in 1030-1215 nm for deep tissue multi-photon microscopy
Energetic ultrafast fiber laser sources tunable in 1030-1215 nm for deep tissue multi-photon microscopy
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DOI：
10.1364/oe.25.006822
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发表时间：
2017-03-20
期刊：
影响因子：
3.8
通讯作者：
Chang, Guoqing
中科院分区：
文献类型：
--
作者：
Liu, Wei;Chia, Shih-Hsuan;Chang, Guoqing
我们展示了一种能量可扩展的方法来实现适用于深层组织多光子显微镜成像的超快光纤激光源。通过光纤非线性（由自相位调制主导），这些独特的超快光源产生持续时间为50-90 fs的近变换限制脉冲，中心波长在1030-1215 nm的波长范围内可调。通过优化光纤色散、缩短光纤长度和使用大模场面积光纤，所得到的脉冲能量可以放大到20 nJ。我们将这样的能量源应用于基于谐波的离体人类皮肤的原理验证研究（即，例如，二次谐波产生和三次谐波产生）成像。这种新型的光纤格式高能超快光源为多光子显微镜应用提供了一个强大的解决方案。(C)2017美国光学学会
We demonstrate an energy scalable approach to implement ultrafast fiber laser sources suitable for deep tissue multi-photon microscopy imaging. Enabled by fiber-optic nonlinearities (dominated by self-phase modulation), these unique ultrafast sources produce nearly transform-limited pulses of 50-90 fs in duration with the center wavelength tunable in the wavelength range of 1030-1215 nm. The resulting pulse energy can be scaled up to 20 nJ by optimizing fiber dispersion, shortening fiber length, and using large-mode-area fibers. We applied such an energetic source to a proof-of-principle study of ex vivo human skin based on harmonics (i. e., second-harmonic generation and third-harmonic generation) imaging. This new type of fiber-format energetic ultrafast source provides a robust solution for multiphoton microscopy applications. (C) 2017 Optical Society of America