Metabolic Regulation of Angiogenesis in Diabetes and Aging.
Metabolic Regulation of Angiogenesis in Diabetes and Aging.
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DOI：
10.1152/physiol.00039.2016
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发表时间：
2017-07
期刊：
影响因子：
8.4
通讯作者：
N. Sawada;Z. Arany
中科院分区：
文献类型：
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作者：
N. Sawada;Z. Arany
血管生成受损和内皮功能障碍是糖尿病和衰老的标志。促进血管生成的临床努力主要集中在生长因子途径上，结果好坏参半。最近，一个新的剧目内皮细胞内的分子内皮细胞代谢的关键已经出现，在调节血管生成中发挥重要作用。因此，本次审查的重点是新兴的重要性和治疗潜力，这些蛋白质和内皮生物能量学在糖尿病和衰老。
Impaired angiogenesis and endothelial dysfunction are hallmarks of diabetes and aging. Clinical efforts at promoting angiogenesis have largely focused on growth factor pathways, with mixed results. Recently, a new repertoire of endothelial intracellular molecules critical to endothelial metabolism has emerged as playing an important role in regulating angiogenesis. This review thus focuses on the emerging importance and therapeutic potential of these proteins and of endothelial bioenergetics in diabetes and aging.