Central nervous system monoamine correlates of social dominance in cynomolgus monkeys (Macaca fascicularis)
Central nervous system monoamine correlates of social dominance in cynomolgus monkeys (Macaca fascicularis)
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DOI：
10.1016/s0893-133x(01)00344-x
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发表时间：
2002-04-01
影响因子：
7.6
通讯作者：
Mann, JJ
中科院分区：
文献类型：
--
作者：
Kaplan, JR;Manuck, SB;Mann, JJ
社会支配是人类和非人类灵长类动物社会性的基本组成部分。然而，它的神经生物学相关性仍然不完全清楚，我们评估了优势地位和脑池脑脊液（CSF）中单胺代谢物浓度之间的关联，在单性社会群体中的成年雄性（n = 25）和雌性（n = 21）食蟹猴（Macaca fascicularis）。测定了多巴胺（高香草酸[HVA]）、去甲肾上腺素（3-甲氧基-4-羟基苯乙二醇[MHPG]）和5-羟色胺（5-羟基吲哚乙酸[5-HIAA]）代谢物的浓度。优势猴（雄性和雌性）的CSF HVA浓度显著高于从属猴（p值
Social dominance is a fundamental component of both human and nonhuman primate sociality. However, its neurobiological correlates remain incompletely understood, We evaluated the association between dominance status and monoamine Metabolite concentrations in cisternal cerebrospinal fluid (CSF) in adult male (n = 25) and female (n = 21) cynomolgus macaques (Macaca fascicularis) housed in unisexual social groups. Concentrations of the metabolites of dopamine (homovanillic acid [HVA]), norepinephrine (3-methoxy-4-hydroxyphenylglycol [MHPG]) and serotonin (5-hydroxyindoleacetic acid [5-HIAA]) were assayed. Dominant monkeys, both males and females, had significantly higher CSF HVA concentrations than did subordinates (p values